Formulating Poorly Water Soluble Drugs

  • Robert O. Williams III
  • Alan B. Watts
  • Dave A. Miller

Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 3)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Stephanie Bosselmann, Robert O. Williams III
    Pages 1-26
  3. Kevin P. O’Donnell, Robert O. Williams III
    Pages 27-93
  4. Justin R. Hughey, Robert O. Williams III
    Pages 95-131
  5. Javier O. Morales, Alan B. Watts, Jason T. McConville
    Pages 133-170
  6. Feng Zhang, James C. DiNunzio
    Pages 171-208
  7. Michael P. Boquet, Dawn R. Wagner
    Pages 209-242
  8. Navnit Shah, Harpreet Sandhu, Duk Soon Choi, Oskar Kalb, Susanne Page, Nicole Wyttenbach
    Pages 267-310
  9. James C. DiNunzio, Feng Zhang, Charlie Martin, James W. McGinity
    Pages 311-362
  10. Dave A. Miller, Marco Gil
    Pages 363-442
  11. Wei Yang, Donald E. Owens III, Robert O. Williams III
    Pages 443-500
  12. Jasmine M. Rowe, Keith P. Johnston
    Pages 501-568
  13. Back Matter
    Pages 631-646

About this book


A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at minimum a working knowledge of each of the abovementioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop. There are numerous literature resources available to pharmaceutical scientists to educate and provide guidance toward formulations development with poorly water-soluble drugs; however, a single, comprehensive reference is lacking. Furthermore, without access to a vast journal library, the detailed methods used to implement these approaches are not available. The objective of this volume is therefore to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules.


AAPS Advances Formulating Miller Pharmaceutical Science Soluble Watts Williams

Editors and affiliations

  • Robert O. Williams III
    • 1
  • Alan B. Watts
    • 2
  • Dave A. Miller
    • 3
  1. 1., Division of PharmacyUniversity of Texas at AustinAustinUSA
  2. 2.College of Pharmacy, Drug Dynamics InstituteUniversity of TexasAustinUSA
  3. 3., Pharmaceutical and Analytical R&DHoffmann-La Roche, Inc.NutleyUSA

Bibliographic information