Crohn's Disease and Ulcerative Colitis

From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach

  • Daniel C. Baumgart

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Epidemiology

    1. Front Matter
      Pages 1-1
    2. Grace N. Gathungu, Judy H. Cho
      Pages 3-16
  3. Immunobiology

    1. Front Matter
      Pages 39-39
    2. Per Brandtzaeg
      Pages 41-74
    3. Emily M. Bradford, Emily S. Turner, Jerrold R. Turner
      Pages 75-84
    4. Till Strowig, Richard A. Flavell
      Pages 111-118
    5. D. Neil Granger, Norman R. Harris
      Pages 133-139
    6. Scott B. Snapper, Deanna D. Nguyen
      Pages 151-159
    7. Atsushi Mizoguchi, Atul K. Bhan
      Pages 161-168
    8. Stephanie Dahan, Vera K. Denmark, Lloyd Mayer
      Pages 175-182
    9. Yasuhiro Nemoto, Mamoru Watanabe
      Pages 183-194
    10. Fridrik Karlsson, Iurii Koboziev, Matthew B. Grisham
      Pages 195-211
  4. Diagnostic Approach

    1. Front Matter
      Pages 213-213
    2. Patrik Rogalla, Tanya Chawla
      Pages 225-243
    3. Joel G. Fletcher
      Pages 245-255
    4. C. Agné, M. Gebel
      Pages 257-275
    5. Nora E. Joseph, Christopher R. Weber
      Pages 287-306
    6. Edouard Louis, Catherine van Kemseke, Catherine Reenaers
      Pages 307-320
    7. Pia Munkholm, Natalia Pedersen
      Pages 333-340
  5. Therapy

    1. Front Matter
      Pages 341-341
    2. Charles N. Bernstein
      Pages 343-363
    3. Miquel A. Gassull, Eduard Cabré
      Pages 365-369
    4. Eoin R. Storan, Laurence Egan
      Pages 387-395
    5. Wojciech Blonski, Gary R. Lichtenstein
      Pages 407-412
    6. Frank Hoentjen, Atsushi Sakuraba, Stephen Hanauer
      Pages 413-432
    7. Barrett G. Levesque, Edward V. Loftus
      Pages 473-480
    8. Julián Panés, Daniel Benítez-Ribas, Azucena Salas
      Pages 503-516
    9. Anne Christine W. Vos, Daniel W. Hommes
      Pages 535-547
    10. Robert R. Cima, John H. Pemberton
      Pages 549-564

About this book


The conditions of Crohn’s disease and ulcerative colitis are excellent examples of  how the exponential growth of knowledge in biomedical science can make a remarkable impact on clinical practice and patient’s quality of life. It has led to the development of unique novel immunomodulatory treatments. These are continuously being refined to treat not only the two original conditions in the gut, but the systemic immunologic illness with its associated extraintestinal disorders. New therapies are sometimes complex and associated with important risks requiring a deeper understanding of their molecular principles from clinicians.


Crohn’s Disease and Ulcerative Colitis serves as a unique combined resource for physicians and scientists addressing the needs of both groups. It will stimulate exchange and collaboration and shorten the path between discovery and application of new knowledge and also help clinicians understand new therapeutic concepts from their origins. This volume provides an introduction to mucosal immunology which forms the basis of modern immunotherapy. It also serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy as well as conventional and complex immunomodulatory principles. Each chapter is written by experts in their field and includes the most up to date information. Crohn’s Disease and Ulcerative Colitis will be of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohn’s disease, ulcerative colitis and related autoimmune disorders.

Editors and affiliations

  • Daniel C. Baumgart
    • 1
  1. 1.Medical School of the Humboldt Universit, Department of MedicineCharité Medical Center, Virchow HospitaBerlinGermany

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2012
  • Publisher Name Springer, Boston, MA
  • eBook Packages Medicine
  • Print ISBN 978-1-4614-0997-7
  • Online ISBN 978-1-4614-0998-4
  • Buy this book on publisher's site