Viral Molecular Machines

  • Michael G. Rossmann
  • Venigalla B. Rao

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 726)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Michael G. Rossmann, Venigalla B. Rao
    Pages 1-3
  3. Kazuhiko Kinosita Jr.
    Pages 5-16
  4. B. V. Venkataram Prasad, Michael F. Schmid
    Pages 17-47
  5. Juan Chang, Xiangan Liu, Ryan H. Rochat, Matthew L. Baker, Wah Chiu
    Pages 49-90
  6. Viral Entry Machines

    1. Front Matter
      Pages 91-91
    2. Petr G. Leiman, Mikhail M. Shneider
      Pages 93-114
    3. Alan R. Davidson, Lia Cardarelli, Lisa G. Pell, Devon R. Radford, Karen L. Maxwell
      Pages 115-142
    4. Sherwood R. Casjens, Ian J. Molineux
      Pages 143-179
    5. Dennis T. Brown, Raquel Hernandez
      Pages 181-199
    6. Ming Luo
      Pages 201-221
    7. Craig B. Wilen, John C. Tilton, Robert W. Doms
      Pages 223-242
  7. Genome Replication Machines

    1. Front Matter
      Pages 243-243
    2. Tom S. Y. Guu, Wenjie Zheng, Yizhi J. Tao
      Pages 245-266
    3. Kyung H. Choi
      Pages 267-304
  8. Capsid Assembly and Maturation

    1. Front Matter
      Pages 305-305
    2. Zacariah L. Hildenbrand, Ricardo A. Bernal
      Pages 307-324
    3. Roger W. Hendrix, John E. Johnson
      Pages 351-363
    4. Sarah J. Butcher, Violeta Manole, Nelli J. Karhu
      Pages 365-377

About this book


A biological organism can be viewed as a collection of molecular machines well integrated to function as a self-replicating unit. One of the principal goals in biology is to be able to fully understand the mechanisms of an organism in atomic detail. Viruses offer the best opportunities to achieve this goal. Written by leaders in the respective fields, this book examines a variety of viral molecular machines, using the best examples from bacteriophages and animal viruses, many causing infectious diseases of public health importance. Beginning with the viral entry into a host cell, the book takes the reader through replication of the genome, assembly of structural components, genome packaging and maturation into an infectious virion. The book conveys the state of the art knowledge of the topic generated by combining X-ray crystallography, high resolution electron microscopy, molecular genetics, biochemistry, and single molecule biophysics. Viral Molecular Machines is not only a “must-have” book for virologists but it will also be broadly useful for molecular biologists in academia and industry as well as an educational tool for teaching graduate and upper level undergraduate students.

Editors and affiliations

  • Michael G. Rossmann
    • 1
  • Venigalla B. Rao
    • 2
  1. 1.Dept. Biological SciencesPurdue UniversityWest LafayetteUSA
  2. 2.Dept. BiologyCatholic University of AmericaWashingtonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2012
  • Publisher Name Springer, Boston, MA
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-0979-3
  • Online ISBN 978-1-4614-0980-9
  • Series Print ISSN 0065-2598
  • About this book