Optical Interferometry for Biology and Medicine

  • David D.┬áNolte

Part of the Bioanalysis book series (BIOANALYSIS, volume 1)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Fundamentals of Biological Optics

    1. Front Matter
      Pages 1-1
    2. David D. Nolte
      Pages 3-48
    3. David D. Nolte
      Pages 49-94
    4. David D. Nolte
      Pages 95-121
    5. David D. Nolte
      Pages 123-145
  3. Molecular Interferometry and Biosensors

    1. Front Matter
      Pages 147-147
    2. David D. Nolte
      Pages 149-175
    3. David D. Nolte
      Pages 177-195
    4. David D. Nolte
      Pages 197-223
  4. Cellular Interferometry

    1. Front Matter
      Pages 225-225
    2. David D. Nolte
      Pages 227-249
    3. David D. Nolte
      Pages 251-272
  5. Interferometry of Biological Tissues

    1. Front Matter
      Pages 273-273
    2. David D. Nolte
      Pages 275-296
    3. David D. Nolte
      Pages 297-306
    4. David D. Nolte
      Pages 307-333
    5. David D. Nolte
      Pages 335-341
  6. Back Matter
    Pages 343-354

About this book


This book presents the fundamental physics of optical interferometry as applied to biophysical, biological and medical research. Interference is at the core of many types of optical detection and is a powerful probe of cellular and tissue structure in interfererence microscopy and in optical coherence tomography. It is also the root cause of speckle and other imaging artefacts that limit range and resolution. For biosensor applications, the inherent sensitivity of interferometry enables ultrasensitive detection of molecules in biological samples for medical diagnostics. In this book, emphasis is placed on the physics of light scattering, beginning with the molecular origins of refraction as light propagates through matter, and then treating the stochastic nature of random fields that ultimately dominate optical imaging in cells and tissue. The physics of partial coherence plays a central role in the text, with a focus on coherence detection techniques that allow information to be selectively detected out of incoherent and heterogeneous backgrounds.

Optical Interferometry for Biology and Medicine is divided into four sections. The first covers fundamental principles, and the next three move up successive scales, beginning with molecular interferometry (biosensors), moving to cellular interferometry (microscopy), and ending with tissue interferometry (biomedical). An outstanding feature of the book is the clear presentation of the physics, with easy derivations of the appropriate equations, while emphasizing "rules of thumb" that can be applied by experimental researchers to give semi-quantitative predictions.

Presents the fundamental physics underlying many biophotonic applications

Reviews the state-of-the-art of interferometric techniques in biology and medicine

Serves as a mathematical reference with complete derivations of results

Includes numerous graphs and figures to help illustrate interference phenomena


cellular interferometry interference phenomena book interfererence microscopy book interferometric biosensors interferometry biological tissue laser speckle light propagation tissue molecular interferometry molecular interferometry description optical coherence tomography optical imaging in cells and tissue physics of light scattering physics of optical interferometry physics of partial coherence

Authors and affiliations

  • David D.┬áNolte
    • 1
  1. 1.Dept. PhysicsPurdue UniversityWest LafayetteUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2012
  • Publisher Name Springer, New York, NY
  • eBook Packages Physics and Astronomy
  • Print ISBN 978-1-4614-0889-5
  • Online ISBN 978-1-4614-0890-1
  • Buy this book on publisher's site