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Retinal Degenerative Diseases

  • Matthew M. LaVail
  • John D. Ash
  • Robert E. Anderson
  • Joe G. Hollyfield
  • Christian Grimm
Conference proceedings

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 723)

Table of contents

  1. Front Matter
    Pages i-lxiv
    PDF

  2. AMD: Basic Mechanisms, Inflammation and Immunity

    1. Front Matter
      Pages 1-1
      PDF
    2. A Window to Innate Neuroimmunity: Toll-Like Receptor-Mediated Cell Responses in the Retina
      Mark E. Kleinman, Jayakrishna Ambati
      Pages 3-9
    3. Autoimmune Biomarkers in Age-Related Macular Degeneration: A Possible Role Player in Disease Development and Progression
      Alessandro Iannaccone, Indira Neeli, Pratheebha Krishnamurthy, Nataliya I. Lenchik, Haibao Wan, Ivan C. Gerling et al.
      Pages 11-16
    4. Local Vs. Systemic Mononuclear Phagocytes in Age-Related Macular Degeneration and Their Regulation by CCL2–CCR2 and CX3CL1–CX3CR1 Chemokine Signalling
      Ulrich F. O. Luhmann, Robin R. Ali
      Pages 17-22
    5. Sublytic Membrane-Attack-Complex Activation and VEGF Secretion in Retinal Pigment Epithelial Cells
      Kannan Kunchithapautham, Mausumi Bandyopadhyay, Mohammad Dahrouj, Joshua M. Thurman, Bärbel Rohrer
      Pages 23-30
    6. Complement Activation in Retinal Degeneration
      Matt Rutar, Riccardo Natoli, Jan Provis, Krisztina Valter
      Pages 31-36
    7. Microglia in the Outer Retina and Their Relevance to Pathogenesis of Age-Related Macular Degeneration
      Wenxin Ma, Lian Zhao, Wai T. Wong
      Pages 37-42
    8. Lutein or Zeaxanthin Supplementation Suppresses Inflammatory Responses in Retinal Pigment Epithelial Cells and Macrophages
      Qingning Bian, Tingyu Qin, Zhihong Ren, Dayong Wu, Fu Shang
      Pages 43-50
    9. Exploring the Potential Role of the Oxidant-Activated Transcription Factor Aryl Hydrocarbon Receptor in the Pathogenesis of AMD
      Goldis Malek, Mary Dwyer, Donald McDonnell
      Pages 51-59
    10. Common Mechanisms for Separate Maculopathies?
      Elod Kortvely, Marius Ueffing
      Pages 61-66
    11. The Role of Amyloid-β in Retinal Degeneration
      Julien Bruban, Virginie Dinet, Frédéric Mascarelli
      Pages 67-74
    12. Molecule-Specific Imaging and Quantitation of A2E in the RPE
      Zsolt Ablonczy, Danielle B. Gutierrez, Angus C. Grey, Kevin L. Schey, Rosalie K. Crouch
      Pages 75-81
    13. Autophagy in the Retina: A Potential Role in Age-Related Macular Degeneration
      Sayak K. Mitter, Haripriya Vittal Rao, Xiaoping Qi, Jun Cai, Andrew Sugrue, William A. Dunn Jr. et al.
      Pages 83-90

  3. Neuroprotection, Drugs and Novel Protective Therapies

    1. Front Matter
      Pages 91-91
      PDF
    2. Regeneration of Cone Outer Segments Induced by CNTF
      Rong Wen, Weng Tao, Lingyu Luo, Deqiang Huang, Konrad Kauper, Paul Stabila et al.
      Pages 93-99
    3. Glucocorticoid-Dependent Mechanisms in Photoreceptor Survival
      Marisa A. Cubilla, Mauricio M. Castañeda, Tomás P. Bachor, Angela M. Suburo
      Pages 101-106
    4. HDAC Inhibition Prevents Rd1 Mouse Photoreceptor Degeneration
      Javier Sancho-Pelluz, François Paquet-Durand
      Pages 107-113
    5. Neuroprotective Dose Response in RCS Rats Implanted with Microphotodiode Arrays
      Machelle T. Pardue, Moon K. Kim, Tiffany A. Walker, Amanda E. Faulkner, Alan Y. Chow, Vincent T. Ciavatta
      Pages 115-120
    6. Treatment with 670-nm Light Protects the Cone Photoreceptors from White Light-Induced Degeneration
      Rizalyn S. Albarracin, Krisztina Valter
      Pages 121-128
    7. Dark-Rearing the rd10 Mouse: Implications for Therapy
      Therese Cronin, Arkady Lyubarsky, Jean Bennett
      Pages 129-136
    8. Intravitreal Injection of Erythropoietin Glycosylation Analogs Does Not Protect Rod Photoreceptor Cells from Light-Induced Damage
      Masaki Tanito, Feng Li, Robert E. Anderson
      Pages 137-143
    9. Relieving Bottlenecks in RNA Drug Discovery for Retinal Diseases
      Jack M. Sullivan, Edwin H. Yau, R. Thomas Taggart, Mark C. Butler, Tiffany A. Kolniak
      Pages 145-153
    10. On Further Development of Barrier Modulation as a Technique for Systemic Ocular Drug Delivery
      Finnian Hanrahan, Matthew Campbell, Anh T. Nguyen, Mayu Suzuki, Anna-Sophia Kiang, Lawrence C. Tam et al.
      Pages 155-159
    11. An Application for Mammalian Optic Nerve Repair by Fish Regeneration-Associated Genes
      Yoshiki Koriyama, Kayo Sugitani, Toru Matsukawa, Satoru Kato
      Pages 161-166
    12. The Mechanism of Fenretinide (4-HPR) Inhibition of β-carotene Monooxygenase 1. New Suspect for the Visual Side Effects of Fenretinide
      Eugenia Poliakov, Alexander Gubin, James Laird, Susan Gentleman, Robert G. Salomon, T. Michael Redmond
      Pages 167-174

  4. Gene Therapy

    1. Front Matter
      Pages 175-175
      PDF
    2. Gene Augmentation Trials Using the Rpe65-Deficient Dog: Contributions Towards Development and Refinement of Human Clinical Trials
      Simon M. Petersen-Jones, Matthew J. Annear, Joshua T. Bartoe, Freya M. Mowat, Susie E. Barker, Alexander J. Smith et al.
      Pages 177-182
    3. Gene Therapy Restores Missing Cone-Mediated Vision in the CNGA3−/− Mouse Model of Achromatopsia
      Stylianos Michalakis, Regine Mühlfriedel, Naoyuki Tanimoto, Vidhyasankar Krishnamoorthy, Susanne Koch, M. Dominik Fischer et al.
      Pages 183-189
    4. Functional Rescue of P23H Rhodopsin Photoreceptors by Gene Delivery
      Marina S. Gorbatyuk, Oleg S. Gorbatyuk, Matthew M. LaVail, Jonathan H. Lin, William W. Hauswirth, Alfred S. Lewin
      Pages 191-197
    5. Gene Delivery of Wild-Type Rhodopsin Rescues Retinal Function in an Autosomal Dominant Retinitis Pigmentosa Mouse Model
      Haoyu Mao, Marina S. Gorbatyuk, William W. Hauswirth, Alfred S. Lewin
      Pages 199-205
    6. Retinal Degeneration and Cellular Suicide
      Wai Gin Fong, Catherine Tsilfidis
      Pages 207-214
    7. Suppression of rds Expression by siRNA and Gene Replacement Strategies for Gene Therapy Using rAAV Vector
      Hilda Petrs-Silva, Douglas Yasumura, Michael T. Matthes, Matthew M. LaVail, Alfred S. Lewin, William W. Hauswirth
      Pages 215-223
    8. Silencing the Expression of CTRP5/C1QTNF5 and ELOVL4 Genes by Small Interfering RNA
      Venkata Ramana Murthy Chavali, Vidyullatha Vasireddy, Radha Ayyagari
      Pages 225-233
    9. Gene Therapy Strategies for Usher Syndrome Type 1B
      David S. Williams, Vanda S. Lopes
      Pages 235-242

  5. Blood Vessels, Angiogenesis, and Neovascularization

    1. Front Matter
      Pages 243-243
      PDF
    2. Neovascularization: Ocular Diseases, Animal Models and Therapies
      Xue Cai, Steven A. Sezate, James F. McGinnis
      Pages 245-252
    3. Retinal Neovascular Disorders: Mouse Models for Drug Development Studies
      Rosanne M. Yetemian, Cheryl M. Craft
      Pages 253-259
    4. A Review and Update on the Molecular Basis of Pathogenesis of Sorsby Fundus Dystrophy
      Heidi Stöhr, Bela Anand-Apte
      Pages 261-267
    5. The Importance of Hypoxia-Regulated, RPE-Targeted Gene Therapy for Choroidal Neovascularization
      George W. Smith, C. Kathleen Dorey, Howard Prentice, Janet Blanks
      Pages 269-277
    6. What Is the Role of CCR3 in Choroidal Neovascularization?
      Yiwen Li, Deqiang Huang, Xin Xia, Zhengying Wang, Lingyu Luo, Rong Wen
      Pages 279-284
    7. Intermittent But Not Constant High Glucose Induces ER Stress and Inflammation in Human Retinal Pericytes
      Yimin Zhong, Joshua J. Wang, Sarah X. Zhang
      Pages 285-292
    8. Regulation of Retinal Vascular Permeability by Betacellulin
      Masahiko Sugimoto, Alecia Cutler, Gregory Grossman, Bela Anand-Apte
      Pages 293-298
    9. Presence of RPE-Produced VEGF in a Timely Manner Is Critical to Choroidal Vascular Development
      Meili Zhu, Yanyan Bai, Lixin Zheng, Yun-Zheng Le
      Pages 299-304
    10. Vasohibin-1 and Retinal Pigment Epithelium
      Yumi Ishikawa, Nobuhiro Nagai, Hideyuki Onami, Norihiro Kumasaka, Ryosuke Wakusawa, Hikaru Sonoda et al.
      Pages 305-310

  6. Genotype/Phenotype

    1. Front Matter
      Pages 311-311
      PDF
    2. Polymorphic Variation of RPGRIP1L and IQCB1 as Modifiers of X-Linked Retinitis Pigmentosa Caused by Mutations in RPGR
      Abigail T. Fahim, Sara J. Bowne, Lori S. Sullivan, Kaylie D. Webb, Jessica T. Williams, Dianna K. Wheaton et al.
      Pages 313-320
    3. RPGRIP1 and Cone–Rod Dystrophy in Dogs
      Tatyana Kuznetsova, Barbara Zangerl, Gustavo D. Aguirre
      Pages 321-328
    4. High-Throughput Approaches for the Genetic Diagnosis of Retinal Dystrophies
      Esther Pomares, Gemma Marfany, Roser Gonzàlez-Duarte
      Pages 329-335
    5. Genes and Mutations in Autosomal Dominant Cone and Cone-Rod Dystrophy
      Susanne Kohl, Veronique Kitiratschky, Monika Papke, Simone Schaich, Alexandra Sauer, Bernd Wissinger
      Pages 337-343

About these proceedings

Introduction

This book will contain the proceedings of the XIV International Symposium on Retinal Degeneration (RD2010), held July 13-17, 2010, in Mont-Tremblant, Quebec, Canada. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy.

Editors and affiliations

  • Matthew M. LaVail
    • 1
  • John D. Ash
    • 2
  • Robert E. Anderson
    • 3
  • Joe G. Hollyfield
    • 4
  • Christian Grimm
    • 5
  1. 1.University of California, San FranciscoSan FranciscoUSA
  2. 2.University of Oklahoma Health Sciences COklahoma CityUSA
  3. 3.Health Science Center, Dean A. McGee Eye Inst.University of OklahomaOKLAHOMA CITYUSA
  4. 4.Division of OphthalmologyCole Eye Institute at the Cleveland ClinClevelandUSA
  5. 5.Experimental OphthalmologyUniversity of ZurichZURICHSwitzerland

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-0631-0
  • Copyright Information Springer Science+Business Media, LLC 2012
  • Publisher Name Springer, Boston, MA
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-0630-3
  • Online ISBN 978-1-4614-0631-0
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site