Insulin-like Growth Factors and Cancer

From Basic Biology to Therapeutics

  • Derek┬áLeRoith
Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Katharina Nimptsch, Edward Giovannucci
    Pages 1-24
  3. Kalina Biernacka, Claire Perks, Jeff Holly
    Pages 25-36
  4. Rosalyn D. Ferguson, Derek LeRoith
    Pages 37-72
  5. Marc A. Becker, Douglas Yee
    Pages 73-84
  6. Rosalyn D. Ferguson, Nyosha Alikhani, Archana Vijayakumar, Yvonne Fierz, Dara Cannata, Shoshana Yakar
    Pages 105-146
  7. Xiaolin Wan, Su Young Kim, Lee J. Helman
    Pages 147-158
  8. Haim Werner, Zohar Attias-Geva, Itay Bentov, Rive Sarfstein, Hagit Schayek, Doron Weinstein et al.
    Pages 159-177
  9. Craig I. Campbell, James J. Petrik, Roger A. Moorehead
    Pages 179-191
  10. Stephen D. Hursting, Sarah D. Smith, Alison E. Harvey, Laura M. Lashinger
    Pages 231-243
  11. Akash Patnaik, Jason W. Locasale, Lewis C. Cantley
    Pages 245-261
  12. Antonino Belfiore, Roberta Malaguarnera
    Pages 263-278
  13. Back Matter
    Pages 279-284

About this book

Introduction

The insulin-like growth factor system has been shown to play a critical role in cancer development and progression. Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics, specifically brings these aspects to the reader. The volume covers the epidemiological aspects of the relationships between circulating insulin and IGF-1 levels and the risk for cancer and cancer-related mortality and in particularly in disease states such as obesity and Type 2 diabetes. It then addresses the basic biology of the system and how the ligands, receptors and IGF-binding proteins affect cancer cell biology and cancer progression. Finally, it discusses the therapeutic potential of inhibiting the receptors using various newly discovered monoclonal antibodies and tyrosine kinase inhibitors that are in preclinical and clinical trials.

Keywords

Cancer Research IGF Leroith Systems Targeted Therapies

Editors and affiliations

  • Derek┬áLeRoith
    • 1
  1. 1., Department of MedicineMount Sinai School of MedicineNEW YORKUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-0598-6
  • Copyright Information Springer Science+Business Media, LLC 2012
  • Publisher Name Springer, Boston, MA
  • eBook Packages Medicine
  • Print ISBN 978-1-4614-0597-9
  • Online ISBN 978-1-4614-0598-6
  • About this book