Human Cell Transformation

Role of Stem Cells and the Microenvironment

  • Johng S. Rhim
  • Richard Kremer

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 720)

Table of contents

  1. Front Matter
    Pages i-xxii
  2. Multistep Models

    1. Front Matter
      Pages 1-1
    2. Vyomesh Patel, Ramiro Iglesias-Bartolome, Bradford Siegele, Christina A. Marsh, Kantima Leelahavanichkul, Alfredo A. Molinolo et al.
      Pages 27-38
    3. Youngmi Ji, Gregory T. Christopherson, Matthew W. Kluk, Orna Amrani, Wesley M. Jackson, Leon J. Nesti
      Pages 39-50
  3. Prostate Cancer/Stem Cells

  4. Breast Cancer/ Stem Cells

    1. Front Matter
      Pages 119-119
    2. Xiangshan Zhao, Channabasavaiah Basavaraju Gurumurthy, Gautam Malhotra, Sameer Mirza, Shakur Mohibi, Aditya Bele et al.
      Pages 135-144
    3. Richard Kremer, Jiarong Li, Anne Camirand, Andrew C. Karaplis
      Pages 145-160
  5. Multistep/Genes

    1. Front Matter
      Pages 161-161
    2. Tom K. Hei, Yongliang Zhao, Hongning Zhou, Vladimir Ivanov
      Pages 163-170
    3. Zacharoula Konsoula, Alfredo Velena, Rachel Lee, Anatoly Dritschilo, Mira Jung
      Pages 171-179
    4. Mira Jung, Olga Timofeeva, Amrita K. Cheema, Rency Varghese, Habtom Ressom, Anatoly Dritschilo
      Pages 181-190
    5. J. Justin McCormick, Veronica M. Maher
      Pages 191-207
  6. Erratum to: Comparative Proteomic Analysis of Mesenchymal Stem Cells Derived from Human Bone Marrow, Umbilical Cord and Placenta: Implication in the Migration

  7. Back Matter
    Pages 217-224

About this book


Rhim and Kremer’s state-of-the-art volume on Human Cell Transformation: Role of Stem Cells and the Microenvironment highlights the latest findings on the current state of human cell transformation model systems and provides the insight into the molecular and cellular changes involved in the conversion of normal cells to neoplastic cells.

Chapters cover all recently developed novel human cell models. In addition, the rapidly growing fields of knowledge regarding not only stem cells in cancer progression, but also the role of the microenvironments in human carcinogenesis are discussed. A wealth of topics is presented including:

·         Derivation of epithelial, fibroblastic, and hematopoietic in vitro model systems

·         Oncogenes

·         Tumor suppressor genes

·         Viral transformation

·         In vitro model systems for viral, chemical and radiation carcinogenesis

·         Cell aging

·         The multistep nature of human carcinogenesis

·         The role of stem cells and the microenvironment in tumorigenesis

·         The genes involved in multistep carcinogenesis

Unique in both scope and focus – devoted solely to human cell transformation systems – Human Cell Transformation: Role of Stem Cells and the Microenvironment provides unparalleled, in-depth coverage for cancer researchers, cell and molecular biologists, hematologists, virologists, and workers in related fields.

Essential reading for everyone who needs to be kept up-to-date in this fast-paced area!



Ø  Multistep models

Ø  Breast cancer/Stem cells

Ø  Prostate cancer/Stem cells

Ø  Multistep / Genes


Cell Human Kremer Rhim Transformation

Editors and affiliations

  • Johng S. Rhim
    • 1
  • Richard Kremer
    • 2
  1. 1.Uniformed Services, Department of SurgeryUniversity of the Health SciencesBethesdaUSA
  2. 2., Department of MedicineMcGill University Health CentreMontrealCanada

Bibliographic information