Hormonal Carcinogenesis

Proceedings of the First International Symposium

  • Jonathan J. Li
  • Satyabrata Nandi
  • Sara Antonia Li

Table of contents

  1. Front Matter
    Pages i-xxxiv
  2. Symposium Presentation

  3. Sex Hormones and Carcinogenesis

    1. Front Matter
      Pages 9-9
    2. Shutsung Liao
      Pages 11-17
    3. Tomoyuki Shirai, Seiko Tamano, Shogo Iwasaki, Nobuyuki Ito
      Pages 27-32
    4. James S. Norris, David A. Schwartz, Tina Cooper, Weimin Fan
      Pages 33-40
  4. Hormones, Cell Proliferation, and Carcinogenesis

    1. Front Matter
      Pages 41-41
    2. Elwood V. Jensen
      Pages 43-50
    3. John A. McLachlan, Retha R. Newbold, Karen G. Nelson, Kenneth S. Korach
      Pages 51-57
    4. Alberto Baldi, Denis M. Boyle, Nestor V. Annibali, James L. Wittliff
      Pages 58-64
    5. Craig W. Beattie, Conwell H. Anderson
      Pages 65-72
    6. Satyabrata Nandi, Raphael C. Guzman, Shigeki Miyamoto
      Pages 73-77
  5. Estrogen Metabolism and Carcinogenicity

    1. Front Matter
      Pages 79-79
    2. Allan H. Conney, Lisa A. Suchar, Shuzo Okumura, Richard L. Chang
      Pages 81-85
    3. Manfred Metzler, Erika Pfeiffer, Werner Köhl, Robert Schnitzler
      Pages 86-94
  6. Hormones and Tumor Promotion

    1. Front Matter
      Pages 119-119

About these proceedings

Introduction

In the past decade there has been a growing public interest and resurgence in research in the field of hormonal carcinogenesis. This is due to the widespread use of therapeutic hormonal agents worldwide and to the increasing awareness of the causal association of hormones, both endogenous and exogenously administered, and a variety of human cancers. These associations include estrogens in uterine, cervical, vaginal, liver, testicular, prostatic, and possible breast cancers; progesterone and progestational hormones in breast cancer; androgens and anabolic steroids in hepatic and prostatic cancers. Additionally, gonadotrophins playa role in the etiology of ovarian and testicular cancers and thyroid-stimulating hormones in thyroid cancers. Therefore, hormonal carcinogenesis encompasses the study of both natural and synthetic hormonal agents, including growth factors and other peptide and protein factors, which contribute substantially to the etiology of both human and animal neoplasms, benign or malignant. Hormones may be involved in all aspects of neoplastic transformation, including initiation, promotion, and progression, and the inhibition of these processes. There are a number of important issues in women's health that need to be addressed. More than 40 million U. S. women are menopausal, and these women have a life expectancy of over 30 years after the menopause. When these figures are multiplied worldwide, the numbers become staggering. After the menopause, estrogen replacement therapy (ERT) is the choice of most women in industrialized countries.

Keywords

breast cancer carcinogenesis hormones liver steroids

Editors and affiliations

  • Jonathan J. Li
    • 1
  • Satyabrata Nandi
    • 2
  • Sara Antonia Li
    • 1
  1. 1.Hormonal Carcinogenesis Laboratory and Department of Pharmaceutical Sciences, College of PharmacyWashington State UniversityPullmanUSA
  2. 2.Department of Molecular and Cell Biology, Cancer Research LaboratoryUniversity of CaliforniaBerkeleyUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4613-9208-8
  • Copyright Information Springer-Verlag New York 1992
  • Publisher Name Springer, New York, NY
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-9210-1
  • Online ISBN 978-1-4613-9208-8
  • About this book