Glycoprotein Hormones

Structure, Function, and Clinical Implications

  • Joyce W. Lustbader
  • David Puett
  • Raymond W. Ruddon
Conference proceedings

Part of the Serono Symposia USA book series (SERONOSYMP)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Reflections Past and Present

    1. Front Matter
      Pages 1-1
    2. Robert J. Ryan
      Pages 8-10
    3. Darrell N. Ward
      Pages 11-15
  3. Regulation of Gene Expression

    1. Front Matter
      Pages 17-17
    2. C. M. Clay, R. A. Keri, D. L. Hamernik, L. L. Heckert, J. H. Nilson
      Pages 19-35
    3. Pamela L. Mellon, David J. Steger, Friedemann Horn, Kerry M. Barnhart, Marita Büscher, Claudia Stauber et al.
      Pages 36-43
    4. Stephen M. Jackson, Kerry M. Barnhart, Pamela L. Mellon, Arthur Gutierrez-Hartmann, James P. Hoeffler
      Pages 44-64
    5. Joel F. Habener, Terry E. Meyer
      Pages 65-74
    6. Bruce D. Weintraub, Myung K. Kim, Donald L. Bodenner, N. Rao Thotakura, Mariusz W. Szkudlinski, Lata Joshi et al.
      Pages 75-78
  4. Hormonal Protein Structure/Function

    1. Front Matter
      Pages 79-79
    2. Joyce W. Lustbader, Chuan Wang, Xiaolu Zhang, Steven Birken, Hao Wu, Jonathan Miles Brown et al.
      Pages 81-102
  5. Protein Processing and Posttranslational Events

    1. Front Matter
      Pages 135-135
    2. Raymond W. Ruddon, Jeffrey R. Huth, Elliott Bedows, Kimberly Mountjoy, Fulvio Perini
      Pages 137-155
    3. Jacques U. Baenziger
      Pages 167-174
  6. Receptor Structure/Function

    1. Front Matter
      Pages 175-175
    2. Motoyasu Saji, Shoichiro Ikuyama, Hiroki Shimura, Toshiaki Ban, Shinji Kosugi, Akinari Hidaka et al.
      Pages 177-216
    3. S. N. Venkateswara Rao, William R. Moyle
      Pages 217-225
    4. Tae H. Ji, Huawei Zeng, Inhae Ji
      Pages 226-249
  7. Clinical Implications

    1. Front Matter
      Pages 251-251
    2. William F. Crowley Jr., Ann E. Taylor, Kathryn A. Martin, Randall C. Whitcomb, Joel S. Finkelstein, Janet E. Hall
      Pages 253-263
    3. D. Bellet, N. Rouas, I. Marcillac, F. Housseau, P. Cottu, F. Troalen et al.
      Pages 264-280
    4. R. E. Canfield, J. F. O’Connor, Y. Chen, S. Birken, M. C. Hatch, K. Friedman et al.
      Pages 281-292
    5. Arleen L. Sawitzke, Jeanine Griffin, William D. Odell
      Pages 321-342
    6. Penelope K. Manasco, Diana L. Blithe, Susan R. Rose, Marie C. Gelato, James A. Magner, Bruce C. Nisula
      Pages 343-348
  8. Back Matter
    Pages 349-381

About these proceedings


Advances in the field of glycoprotein hormones necessitated a second international symposium on this topic, held March 11 to 14, 1993, in Santa Barbara, California, and again sponsored by Serono Symposia, USA. The meeting was twofold in its concept: (1) the dissemination of the current research in the field and (2) honoring three scientists who have greatly contributed to this field, Drs. Harold Papkoff, Robert Ryan, and Darrell Ward, upon their retirements. We were honored to have Dr. John Pierre present as a participant at the meeting and also serving as master of ceremonies at the banquet. Certainly one of the highlights at the first meeting, held in 1989, was the cloning of the CG/LH receptor. This second meeting was also filled with insightful and innovative scientific presentations. Significant advances in the regulation of gene transcription of the gonadotropins were presented by Pamela Mellon, James Hoeffler, John Nilson, Bruce Weintraub, and Joel Habener. These presentations reflected major advances from the in the understanding concepts offered at the last meeting. Other advances of hormone structure/function included the continuing work by Joyce Lustbader on the determination of the three-dimensional structure of hCG, including a new approach using nonisotopic labels for 3-D and 4-D NMR imaging. New insights into biosynthesis of hCG were proposed by Irving Boime. Studies directed at identifying receptor contact regions were presented by Henry Keutmann and David Puett.


Expression Protein Regulation Translation gene expression metabolism tertiary structure transcription

Editors and affiliations

  • Joyce W. Lustbader
    • 1
  • David Puett
    • 2
  • Raymond W. Ruddon
    • 3
  1. 1.Irving Center for Clinical Research Columbia University College of Physicians and SurgeonsNew YorkUSA
  2. 2.Department of BiochemistryUniversity of GeorgiaAthensUSA
  3. 3.Eppley Institute for ResearchUniversity of Nebraska Medical CenterOmahaUSA

Bibliographic information