Biology and Management of Lung Cancer

  • F. Anthony Greco

Part of the Cancer Treatment and Research book series (CTAR, volume 11)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Desmond N. Carney, Adi F. Gazdar, Herbert K. Oie, Francis Cuttitta, John D. Minna
    Pages 1-24
  3. Frank Cuttitta, Steven Rosen, Desmond N. Carney, Adi F. Gazdar, John D. Minna
    Pages 25-36
  4. Stephen A. Sherwin, George J. Todaro
    Pages 37-49
  5. S. Kent Callahan, Charles A. Coltman Jr., Cliff Kitten, Daniel D. Von Hoff
    Pages 51-71
  6. John M. Lukeman, Bruce Mackay
    Pages 87-108
  7. Mehmet F. Fer, William W. Grosh, F. Anthony Greco
    Pages 109-124
  8. Rowan T. Chlebowski, David Heber, Jerome B. Block
    Pages 125-142
  9. William G. North, L. Herbert Maurer, Joseph F. O’Donnell
    Pages 143-169
  10. Kenneth R. Hande, Arnold W. Malcolm
    Pages 191-217
  11. Back Matter
    Pages 219-222

About this book


Lung cancer remains an extremely difficult neoplasm to treat effectively. A large part of our lack of success in dealing with these patients is related to our empiric therapeutic attempts. Slowly our basic understanding of the lung cancers is improving and techniques are becoming available to allow us to better understand the biology of these neoplasms. This volume reviews several areas of interest in regard to the biologic behavior and characteris­ of lung cancer. tics Chapters deal with the in vitro growth of small cell lung cancer, the inves­ tigation of growth factors in human lung cancer, the production of mono­ clonal antibodies against lung cancer and the application and potential use­ fulness of the human tumor cloning assay in lung cancer management. These avenues of investigation are likely to establish a more scientific basis on which more rational therapy can be designed. Carney and associates have established several continuous small cell lung cancer cell lines in their laboratory. The amine precursor uptake and decar­ boxylation (APUD) properties of this neoplasm have been confirmed by demonstrating the presence of neurosecretory granules and high levels of the APUD enzyme L-dopa decarboxylase. In addition, several new markers have been documented including bombesin, creatine-kinase BB and neuron­ specific enolase. These tumor products along with others may be useful serum markers in patients with small cell lung cancer.


carcinoma cell surgery transplantation tumor

Editors and affiliations

  • F. Anthony Greco
    • 1
  1. 1.Department of MedicineVanderbilt University Medical CenterNashvilleUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1983
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-3851-2
  • Online ISBN 978-1-4613-3849-9
  • Series Print ISSN 0927-3042
  • Buy this book on publisher's site