Protein Conformation as an Immunological Signal

  • Franco Celada
  • Verne N. Schumaker
  • Eli E. Sercarz

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Influence of Antigen upon Conformation of Antibody

    1. Franco Celada, Verne N. Schumaker, Eli E. Sercarz
      Pages 1-2
    2. Péter Závodszky, Ferenc Kilár, Judit Török, György A. Medgyesi
      Pages 15-29
    3. B. Parodi, V. Dessi, P. Casali, R. Strom, F. Celada
      Pages 31-44
  3. Structure/Function Interrelationships in IgM and IgG

    1. Franco Celada, Verne N. Schumaker, Eli E. Sercarz
      Pages 45-46
    2. A. Feinstein, N. E. Richardson, B. D. Gorick, N. C. Hughes-Jones
      Pages 47-57
    3. Kathryn D. Crossland, Marian E. Koshland
      Pages 59-72
    4. Dennis R. Burton, Raymond A. Dwek, Jirí Novotný
      Pages 73-81
    5. R. Bragado, J. A. López de Castro, F. Ortiz, F. Vivanco
      Pages 83-94
  4. Structure of C1, Interactions between Its Subunits and with Other Macromolecules

    1. Franco Celada, Verne N. Schumaker, Eli E. Sercarz
      Pages 95-96
    2. Verne N. Schumaker, Pak H. Poon
      Pages 97-114
    3. J. Cseh, L. Jakab, T. Pozsonyi, J. Fehér
      Pages 115-117
    4. Gérard J. Arlaud, Jean Gagnon, Rodney R. Porter
      Pages 131-135
  5. The Activation of the First Component of Complement

    1. Franco Celada, Verne N. Schumaker, Eli E. Sercarz
      Pages 137-138
    2. Erich Kilchherr, Harald Fuchs, Jurg Tschopp, Jurgen Engel
      Pages 139-140
    3. Maurice G. Colomb, Cristian L. Villers, Gérard J. Arlaud
      Pages 141-147
    4. Else Marie Nicolaisen
      Pages 149-154
  6. The Importance of Antigen Conformation for Antigenicity and Immunogenicity

    1. Franco Celada, Verne N. Schumaker, Eli E. Sercarz
      Pages 155-156
    2. Jay A. Berzofsky, Gail K. Buckenmeyer, Gloria Hicks, Douglas J. Killion, Ira Berkower, Yoichi Kohno et al.
      Pages 165-180
    3. Marc H. V. Van Regenmortel, Danièle Altschuh, Jean-Paul Briand
      Pages 181-190
  7. The Changes in Protein Antigen Conformation Induced by Antibody

    1. Franco Celada, Verne N. Schumaker, Eli E. Sercarz
      Pages 211-212
    2. Roberto S. Accolla, Renata Cina’, Elisabetta Montesoro, Franco Celada
      Pages 213-216
    3. Irving Zabin, Audrèe V. Fowler, Franco Celada
      Pages 225-231
    4. Roberto Strom, Jasna Radojkovic, Paola Minale, Franco Celada
      Pages 233-241
  8. The Recognition By T Cells of Protein Antigens

    1. Franco Celada, Verne N. Schumaker, Eli E. Sercarz
      Pages 243-244
    2. Which are the Antigenic Determinants that T Cells Recognize?

      1. David C. Benjamin, Lise A. Daigle, Richard L. Riley
        Pages 261-280
      2. Giampietro Corradin, Serge Carel, Yolande Buchmüller, Patrick Amiguet, Howard D. Engers, Claude Bron
        Pages 281-287
      3. Ira Berkower, Gail K. Buckenmeyer, Frank R. N. Gurd, Jay A. Berzofsky
        Pages 289-300
    3. What is the Role of MHC and other Genes in the Antigen Presenting Cell?

      1. C. Shirley Lin, Ted. H. Hansen, Lanny T. Rosenwasser, Brigitte T. Huber, Alan S. Rosenthal
        Pages 303-313
      2. Alexander Miller
        Pages 315-321
      3. R. B. Taylor, C. A. Morrison
        Pages 337-345
    4. Analysis of the Ternary Complex of Antigen: MHC: and T-Cell Receptor with T Cell Clones

      1. E. Rüde, A. B. Reske-Kunz, E. Spaeth
        Pages 349-358
      2. Ellen Heber-Katz, Daniel Hansburg, Ronald H. Schwartz
        Pages 359-360
  9. Structural Aspects of T-B and T-T Interaction

    1. Franco Celada, Verne N. Schumaker, Eli E. Sercarz
      Pages 369-371
    2. Joel W. Goodman, Danute E. Nitecki, Sherman Fong, Zehra Kaymakcalan
      Pages 373-378
    3. Douglas R. Green, Richard K. Gershon
      Pages 387-394
    4. Trond Jørgensen, Bjarne Bogen, Kristian Hannestad
      Pages 419-428

About this book


This volume is the collection of papers presented during a four day meeting, the EMBO workshop "Protein Conformation as an Immunological Signal" that took place at Portovenere (La Spezia), Italy, October 1-4, 1981. The motivation that drove us to organize this meeting was the feeling that distinct groups of researchers, active in key areas of modern immunology, sometimes fail to communicate with each other simply because of different traditional affiliations. Yet it is urgent that "molecular" and "cellular" people cooperate more if immunology is to continue the exportation of new concepts to other disciplines. In fact, the deep meaning of molecule-molecule and cell-cell interaction, the generation of signals and their effective transmission which results in elicitation, control or suppression of responses cannot be unraveled without the experts on antibody structure or complement activation sharing their views with the experts on T cell, B cell and macrophage membrane receptors as well as the experts on factors that carry the information released by these cells. Whether the meeting was scientifically fruitful, the reader can judge after having digested these pages. We, the organizers, are not sure whether the optimal amount·of interaction had taken place; especially considering how hard it is to overcome the scientist's catch 22: You have to know something quite well before you get really interested in it. In any event, we are convinced that Portovenere was one of the most successful attempts we have witnessed.


T cell Vine antibody cells enzyme enzymes immune response influence kinetics lymphocytes paper protein receptor system virus

Editors and affiliations

  • Franco Celada
    • 1
  • Verne N. Schumaker
    • 2
  • Eli E. Sercarz
    • 2
  1. 1.University of GenoaGenoaItaly
  2. 2.University of CaliforniaLos AngelesUSA

Bibliographic information