Nutritional Elements and Clinical Biochemistry

  • Marge A. Brewster
  • Herbert K. Naito

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Donald E. Hill
    Pages 1-13
  3. Surat Komindr, George E. Nichoalds
    Pages 15-68
  4. Herbert K. Naito
    Pages 69-115
  5. C. Bruce Taylor, Shi-Kaung Peng
    Pages 131-138
  6. Raymond J. Shamberger
    Pages 241-275
  7. Francine M. Hoerrmann, Donna B. Rosenstock, Herbert K. Naito
    Pages 317-356
  8. Lena A. Lewis, Herbert K. Naito, Irvine H. Page, Bruce A. Sebek
    Pages 357-382
  9. Jon A. Story
    Pages 383-396
  10. James D. Jones, Mary A. Jones
    Pages 397-408
  11. Paul M. Tocci
    Pages 409-419
  12. Alvin Dubin, Shibban Ganju, Paul B. Szanto, Ann Poulos, Frederick Steigmann
    Pages 421-435
  13. Back Matter
    Pages 451-463

About this book


The important role that the nutritional status exerts in determining the course of life from birth to death in the human being and especially its impact in disease states is only par­ tially appreciated at this time. Nutritional deficiencies are usually considered to be major problems only in under-privileged or developing populations, except for those occurring in specific diseases. This attitude is incorrect as indicated by reports of Bestrian et al (1974, 1976) and Merritt and Suskin (1979) and others who found evidence of nutritional depletion in as much as 50% of the patients in varied groups of hospitalized patients in the United States. Other studies, some of which are included in this book, emphasized the existence of deficiencies of certain specific nutrients. Despite evidence of nutritional deficiencies occurring more frequently than previously appreciated, there is no well established protocol of laboratory studies that the clinical chemist or scientist should provide to help the physician detect lack of essential nutrients before extensive and possibly irreparable damage has occurred to the individual patient. Considerable research data are needed to determine the best biologic material (i.e., erythrocytes, leucocytes, plasma, serum, urine, cerebrospinal fluid, lymph) for analysis to determine accurately at an early stage metabolic deficiencies due to a specific nutritional element. Improved techniques for analysis of key metabolites and nutrients are available in the research labora­ tory and many of them can be adapted to the clinical laboratory.


Metabolite Retinol Riboflavin Vitamin A Vitamin C Vitamin D Vitamin E amino acid diabetes diabetes mellitus genetics health intestinal microflora metabolism nutrition

Editors and affiliations

  • Marge A. Brewster
    • 1
    • 2
  • Herbert K. Naito
    • 3
    • 4
  1. 1.Departments of Pathology, Biochemistry, and PediatricsUniversity of Arkansas for Medical SciencesLittle RockUSA
  2. 2.Metabolic LaboratoryArkansas Children’s HospitalLittle RockUSA
  3. 3.Department of Biochemistry, Division of Laboratory Medicine, Department of A therosclerosis and Thrombosis Research, Division of ResearchCleveland Clinic FoundationClevelandUSA
  4. 4.Department of ChemistryCleveland State UniversityClevelandUSA

Bibliographic information