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Platinum Coordination Complexes in Cancer Chemotherapy

Proceedings of the Fourth International Symposium on Platinum Coordination Complexes in Cancer Chemotherapy convened in Burlington, Vermont by the Vermont Regional Cancer Center and the Norris Cotton Cancer Center, June 22–24, 1983

  • Miles P. Hacker
  • Evan B. Douple
  • Irwin H. Krakoff

Part of the Developments in Oncology book series (DION, volume 17)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Nomenclature

    1. Front Matter
      Pages 1-1
  3. Biochemistry of Platinum Coordination Complexes in Cancer Chemotherapy

    1. Front Matter
      Pages 9-9
    2. S. J. Lippard
      Pages 11-13
    3. J. P. Macquet, J. L. Butour, N. P. Johnson, H. Razaka, B. Salles, C. Vieussens et al.
      Pages 27-38
    4. J. Reedijk, J. H. J. den Hartog, A. M. J. Fichtinger-Schepman, A. T. M. Marcelis
      Pages 39-63
  4. Pharmacology and Pharmacodynamics of Platinum Coordination Complexes in Cancer Chemotherapy

    1. Front Matter
      Pages 65-65
    2. C. L. Litterst
      Pages 67-70
    3. P. V. Woolley, V. M. Priego, P. V. T. Luc, A. Rahman, P. S. Schein
      Pages 82-89
    4. Z. H. Siddik, D. R. Newell, F. E. Boxall, M. Jones, K. G. McGhee, K. R. Harrap
      Pages 90-102
    5. L. Pendyala, J. W. Cowens, S. Madajewicz, P. J. Creaven
      Pages 114-125
    6. L. A. Sternson, A. J. Repta, H. Shih, K. J. Himmelstein, T. F. Patton
      Pages 126-147
  5. Toxicology of Platinum Coordination Complexes in Cancer Chemotherapy

    1. Front Matter
      Pages 149-149
    2. M. P. Hacker
      Pages 151-153
    3. R. F. Borch, D. L. Bodenner, J. C. Katz
      Pages 154-164
    4. J. E. Schurig, A. P. Florczyk, W. T. Bradner
      Pages 187-209
  6. Development of New Platinum Coordination Complexes

    1. Front Matter
      Pages 211-211
    2. M. J. Cleare
      Pages 213-215
    3. A. H. Calvert, S. J. Harland, K. R. Harrap, E. Wiltshaw, I. E. Smith
      Pages 240-263
  7. Non-Platinum Metal Complexes as Antitumor Agents

  8. Unique Therapeutic Approaches Using Platinum Coordination Complexes

    1. Front Matter
      Pages 305-305
    2. J. Burchenal
      Pages 307-309
    3. J. B. Vermorken, W. W. Bokkel ten Huinink, J. G. McVie, W. J. F. van der Vijgh, H. M. Pinedo
      Pages 330-356
  9. David B. Brown Memorial Lecture

    1. Front Matter
      Pages 357-357
    2. S. K. Carter
      Pages 359-376
  10. Back Matter
    Pages 377-384

About this book

Introduction

The idea for convening a Fourth International Symposium on Platinum Coordination Complexes in Cancer Chemotherapy was born in an assembly of researchers from the Vermont Regional Cancer Center and the Norris Cotton Cancer Center who shared a common interest in metal complexes. It was agreed by those assembled that sufficient time had passed since the Third International Symposium on Platinum Coor­ dination Complexes in Cancer Chemotherapy held in 1976 at the Wadley Institutes of Molecular Medicine in Dallas, Texas, during which several advances in the chemistry, biochemistry, pharmacology and clinical use of platinum complexes had occurred, to warrant a fourth symposium. Furthermore, intensive investigations in progress were bringing sophisticated methodologies to bear on the problems in the field, clinical trials were yielding interesting results, and unique approaches to cancer therapy were being designed. Therefore, an organizing committee was formed and planning culminated in the symposium which was held in Burlington, Vermont, June 22-24, 1983.

Keywords

cancer cancer therapy chemotherapy clinical trial pharmacology

Editors and affiliations

  • Miles P. Hacker
    • 1
  • Evan B. Douple
  • Irwin H. Krakoff
  1. 1.Vermont Regional Cancer Center and Department of PharmacologyUniversity of VermontBurlingtonUSA

Bibliographic information