Individual Susceptibility to Genotoxic Agents in the Human Population

  • Frederick J. de Serres
  • Ronald W. Pero

Part of the Environmental Science Research book series (ESRH, volume 30)

Table of contents

  1. Front Matter
    Pages i-x
  2. Genotoxic Substances and Variability in Human Disease

    1. M. D. Waters, J. W. Allen, L. D. Claxton, N. E. Garrett, S. L. Huang, M. M. Moore et al.
      Pages 53-87
  3. Metabolism of Genotoxic Agents in Human Cells and its Relevance to Risk Assessment

    1. Jan Åke Gustafsson, Jan Carlstedt-Duke, Mikael Gillner, Lars-Arne Hansson, Bertil Högberg, Johan Lund et al.
      Pages 89-108
    2. G. Clare Kahn, Alan R. Boobis, Donald S. Davies
      Pages 109-153
    3. Peter Moldéus, Bo Andersson, Roger Larsson, Magnus Nordenskjöldt
      Pages 155-162
    4. Alf Fischbein, J. George Bekesi, Irving J. Selikoff, Ernest Borek
      Pages 163-175
  4. Genotoxic Testing on Somatic Cells in the Human Population

  5. Evaluation of Body Tissues and Fluids as Indicators of Exposure

  6. Population Heterogeneity as a Modifier of Genotoxic Response

  7. Reproductive Effects of Genotoxic Exposures on the Human Population

  8. Genotoxic Risk Monitoring of the General Population

  9. Back Matter
    Pages 503-518

About this book


As a result of the industrial revolution, man's technological achievements have been truly great, increasing the quality of life to almost unimagined proportions; but all this progress has not been accomplished without equally un imagined health risks. Sufficiently diagnostic short-term assay procedures have been developed in recent years for us to determine that there are mutagenic agents among thou­ sands of chemicals to which the human population is exposed today. These chemicals were not significantly present prior to the indus­ trial revolution. As of today, there are no procedures available which have been adequately demonstrated to assess individual sus­ ceptibility to genotoxic exposures, and as a result we have had to rely on extrapolating toxicological data from animal model systems. The question is can we afford to allow such an increased environ­ mental selection pressure via mutagenic exposures to occur without expecting adverse long-term effects on our health. It is apparent from this line of reasoning that what is lacking and immediately needed are test procedures that can be applied to humans to assess genotoxic exposure as well as individual susceptibility to it. There have already been two conferences which have focused at­ tention on this research area. "Guidelines for studies of human populations exposed to mutagenic and reproductive hazards" (A. D. Bloom, ed., March of Dimes Birth Defects Foundation, White Plains, New York, 1981) and "Indicators of genotoxic exposure in humans" (Banbury Report 13, B. A. Bridges, B. E. Butterworth, and I. B.


environment environmental health health risk assessment

Editors and affiliations

  • Frederick J. de Serres
    • 1
  • Ronald W. Pero
    • 2
  1. 1.Research Triangle ParkNational Institute of Environmental Health SciencesUSA
  2. 2.University of LundLundSweden

Bibliographic information