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Mechanisms of Cancer Metastasis

Potential Therapeutic Implications

  • Kenneth V. Honn
  • William E. Powers
  • Bonnie F. Sloane
Book

Part of the Developments in Oncology book series (DION, volume 40)

Table of contents

  1. Front Matter
    Pages i-xv
  2. William E. Powers
    Pages 1-14
  3. Victor Ling
    Pages 81-90
  4. Prasad S. Sunkara, Nellikunja J. Prakash
    Pages 91-101
  5. K. V. Honn, J. M. Onoda, D. G. Menter, P. G. Cavanaugh, J. D. Crissman, J. D. Taylor et al.
    Pages 117-144
  6. Peter Alexander, Paul V. Senior, Paul Murphy, Richard Clarke
    Pages 173-191
  7. Richard J. Ford, Frances Davis, Nicola Kouttab, Shashi Mehta
    Pages 193-205
  8. Garth L. Nicolson, Motowo Nakajima, Tatsuro Irimura
    Pages 275-297
  9. Lance A. Liotta, Nageswara C. Rao, Sanford H. Barsky, Taina M. Turpeenniemi-Hujanen
    Pages 299-308
  10. James Quigley, Eva Cramer, Sandra Fairbairn, Rhonda Gilbert, Janis Lacovara, George Ojakian et al.
    Pages 309-339
  11. Bonnie F. Sloane, Jurij Rozhin, Randall E. Ryan, Tamara T. Lah, Nancy A. Day, John D. Crissman et al.
    Pages 377-397
  12. John D. Crissman, Kenneth V. Honn
    Pages 399-417
  13. Back Matter
    Pages 419-428

About this book

Introduction

The past twenty years have witnessed significant advances in the treatment of cancer by surgery and radiation therapy. Gains with cytotoxic chemotherapy have been much more modest. Of the approximately 900,000 newly diagnosed cases of cancer each year, 50010 result in death of the patient. The primary cause of these deaths is metastasis. Although the term metastasis was first coined by Recamier in 1829, only in the past ten years have there been intensive scientific investigations into the mechanisms by which tumor cells metastasize. What has emerged is a complex process of host-tumor cell interactions which has been termed the metastatic cascade. Due to the complexity of the metastatic process, the study of metastasis is multifaceted and involves elements of such areas as differentiation, en­ zymology, genetics, hematology, immunology, membrane biochemistry and molecular biology. The major objectives of this book were to present the most recent advances in our understanding of how tumor cells metastasize to secondary sites by the leading experts in the biology of tumor invasion and metastasis. We hope that this book will lead to new concepts for the treatment of subclinical metastatic cancer. The chapters in this book address both the basic science of metastasis and potential clinical therapies directed toward interruption of the metastatic cascade or toward eradication of subclinical metastases. Many relevant topics have been omitted due to space considerations and thus the topics included reflect the prej­ udices of the editors.

Keywords

cancer treatment cell genetics hematology macrophages melanoma metastasis metastatic disease molecular biology pathogenesis surgery tumor tumor growth

Editors and affiliations

  • Kenneth V. Honn
    • 1
  • William E. Powers
    • 2
  • Bonnie F. Sloane
    • 3
  1. 1.Department of Radiation OncologyWayne State University Harper-Grace HospitalDetroitUSA
  2. 2.Department of Radiation OncologyWayne State UniversityDetroitUSA
  3. 3.Department of PharmacologyWayne State UniversityDetroitUSA

Bibliographic information