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Epilepsy and the Corpus Callosum

  • Alexander G. Reeves

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Anatomy, Development, and Physiology

  3. Experimental Epilepsy

  4. Clinical Epilepsy

    1. Front Matter
      Pages 235-235
    2. Robert J. Joynt
      Pages 237-241
    3. Peter D. Williamson
      Pages 243-257
    4. David W. Roberts
      Pages 259-267
    5. Alexander G. Reeves, Patrick M. O’Leary
      Pages 269-280
    6. Raul Marino Jr., Paulo C. Ragazzo
      Pages 281-301
    7. Jean-Marc Saint-Hilaire, Normand Giard, Guy Bouvier, Raymonde Labrecque
      Pages 303-314
    8. John R. Gates, Robert Maxwell, Ilo E. Leppik, Miguel Fiol, Robert J. Gumnit
      Pages 315-328
  5. Neuropsychology

    1. Front Matter
      Pages 339-339
    2. John J. Sidtis
      Pages 369-380
    3. Frank E. Musiek, Karen S. Kibbe
      Pages 393-399
    4. Makoto Iwata, Yasuo Toyokura
      Pages 401-415
    5. Morihiro Sugishita, Akira Shinohara, Takeyoshi Shimoji, Tetsuro Ogawa
      Pages 417-434
    6. C. H. P. Camargo, R. M. A. Makray, J. Radvany, R. Marino Jr.
      Pages 435-449
    7. Walter F. McKeever, Kathleen F. Sullivan, Shirley M. Ferguson, Mark Rayport
      Pages 451-466
    8. Robert A. Novelly, Maria Deinzer Lifrak
      Pages 467-500
    9. Shirley M. Ferguson, Mark Rayport, W. Stephen Corrie
      Pages 501-514
    10. Joseph E. Bogen
      Pages 515-524
  6. Back Matter
    Pages 525-534

About this book

Introduction

InJuly 1982 the first Dartmouth workshop on the corpus callosum took place. A nucleus of basic and clinical scientists was convened to give progress reports of their work on the corpus callosum. This text was subsequently compiled by the various participants from these reports modified by a stimulating cross­ fertilization of ideas and subsequent studies. Four and one-half decades have intervened since Van Wagenen first sectioned the corpus callosum for epilepsy (Van Wagenen and Herren, 1940) and Erickson (1940) demonstrated that the corpus callosum is the major route for generalization of experimentally induced focal cortical epilepsy. During the succeeding 45 years a handful of clinicians has pursued these leads to confirm the therapeutic value of callosotomy for some types of medically intractable generalized epilepsy. Parallel experimental studies with a number of epilepsy models have indicated that the corpus callosum is indeed the major route for seizure generalization, that the brainstem is a secondary and more resistant pathway for seizure generalization, and that most if not all epileptic seizures originate from the cerbral cortex. The unexpected clinical finding that even partial (focal) seizure incidence is modified by callosotomy now has been demonstrated in the laboratory. The various contributors to the clinical and experimental epilepsy sections of this volume have been seminal in these elucidations, as will be evident from their chapters. The section on the development, anatomy, and physiology of the corpus callosum demonstrates that these basic areas of study have not been neglected.

Keywords

Epilepsie anatomy brainstem cortex forebrain physiology

Editors and affiliations

  • Alexander G. Reeves
    • 1
  1. 1.Dartmouth-Hitchcock Medical CenterHanoverUSA

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