Amyloidosis

  • George G. Glenner
  • Elliott F. Osserman
  • Earl P. Benditt
  • Evan Calkins
  • Alan S. Cohen
  • Dorothea Zucker-Franklin

Table of contents

  1. Front Matter
    Pages i-xvii
  2. SAA, AA, and AP Proteins

    1. Front Matter
      Pages 1-1
    2. Nils Eriksen, Earl P. Benditt
      Pages 3-10
    3. B. Skogen, K. Sletten, T. Lea, J. B. Natvig
      Pages 11-18
    4. Per Westermark, Gunilla T. Nilsson
      Pages 19-26
    5. A. C. J. van Andel, P. R. Hol, J. H. van der Maas, E. T. G. Lutz, H. Krabbendam, E. Gruys
      Pages 39-48
    6. W. G. Turnell, R. Sarra, I. D. Glover, J. O. Baum, D. Caspi, M. L. Baltz et al.
      Pages 49-55
    7. J. D. Sipe, P. Woo, G. Goldberger, A. S. Cohen, A. S. Whitehead
      Pages 57-60
    8. George H. Sack Jr., John J. Lease
      Pages 61-68
    9. C. J. Rosenthal, N. Solomon, M. E. Martin
      Pages 69-77
    10. Shunsuke Migita, Shigeru Hashimototo, Haruo Hisazumi, Mine Harada, Hiroaki Okabe
      Pages 87-97
  3. Experimental Models

    1. Front Matter
      Pages 99-99
    2. M. L. Baltz, D. Caspi, I. F. Rowe, C. R. K. Hind, D. J. Evans, M. B. Pepys
      Pages 101-108
    3. Ronald I. Carr, Judith Katilus, D. Petty
      Pages 109-113
    4. M. L. Baltz, D. Caspi, C. R. K. Hind, A. Feinstein, M. B. Pepys
      Pages 115-121
    5. G. Marhaug, A. Husebekk, G. Husby, K. Sletten, A. L. Børresen, B. Lium et al.
      Pages 139-147

About this book

Introduction

From a process that from the days of Vir chow and Rokitansky, primarily stimulated the relatively narrow interest of pathologists, amyloidosis has risen full-blown as one of the most important of disease complexes. Its presence dominat:es the lesions of Alzheimer's disease, a disease affecting an estimated 2. 5 million people in the U. S. A. and thereby closely rivaling stroke as the third most common cause of death. If, as it has been de­ scribed, Alzheimer's disease is the "Disease of the Century," then amy­ loidosis is the Disease Complex of the Ages. It affects in one or more of its manifestations every organ of the body, and is at least as old as the afflicted Egyptian mummies of the pyramids. With an increasing percentage of older individuals amyloid of the senior population becomes increasingly more frequent. The subjects covered in this Symposium range through almost every clinical medical specialty. From an average of one paper in each of the past three Symposiums, the explosive interest in cerebral amyloidosis has led to the presentation of 12 papers on this subject in the present volume. The genetically predisposed familial amyloidotic processes, such as the polyneuropathies and familial Mediterranean fever have also stimulated ex­ tensive and intriguing investigations which have revealed the striking effect of a single amino acid substitution in transforming a normal protein into. a lethal "amyloidogenic" one.

Keywords

Alzheimer's disease Alzheimer´s disease Syndrom dementia diagnosis inflammation nervous system syndromes tumor

Editors and affiliations

  • George G. Glenner
    • 1
  • Elliott F. Osserman
    • 2
  • Earl P. Benditt
    • 3
  • Evan Calkins
    • 4
  • Alan S. Cohen
    • 5
  • Dorothea Zucker-Franklin
    • 6
  1. 1.University of CaliforniaSan Diego La JollaUSA
  2. 2.Columbia UniversityNew YorkUSA
  3. 3.University of WashingtonSeattleUSA
  4. 4.State University of New York at BuffaloBuffaloUSA
  5. 5.Boston University School of MedicineBostonUSA
  6. 6.New York University School of MedicineNew YorkUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4613-2199-6
  • Copyright Information Springer-Verlag US 1986
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-9292-0
  • Online ISBN 978-1-4613-2199-6
  • About this book