Clinical Applications of Continuous Infusion Chemotherapy and Concomitant Radiation Therapy

  • C. Julian Rosenthal
  • Marvin Rotman

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Protracted Administration of Antineoplastic Chemotherapy Agents

    1. Front Matter
      Pages 1-1
    2. Principles and Therapeutic Applications

    3. Clinical Studies

      1. Morton Coleman, D. Barry Boyd, Bernard Bernhardt, Gary Gerstein, Samuel Kopel
        Pages 79-86
      2. L. Helson, M. A. Castello, E. Arenson, L. Steinherz, S. Groshen
        Pages 91-94
      3. Farida Chaudhri, Steven L. Allen, Philip Schulman, Willi Kreis, Daniel R. Budman, Lora Weiselberg et al.
        Pages 95-100
      4. P. Salem, M. Khalyl, K. Jabboury, L. Hashimi
        Pages 101-105
  3. Antineoplastic Effects of Radiation Therapy and Chemothrapy by Continuous Unfusion

    1. Front Matter
      Pages 111-111
    2. Principles and Therapeutic Applications

    3. Clinical Studies

      1. M. Rotman, K. Choi, S. Isaacson, J. Rosenthal, A. Braverman, J. Marti
        Pages 189-193
      2. H. W. Merrick, R. R. Dobelbower Jr, J. F. Ringleint, R. T. Skeel
        Pages 195-199
      3. Oscar A. Mendiondo, Lawerence C. Maguire, William D. Medina, John D. Cronin
        Pages 201-205
      4. J. H. Jenrette III, R. D. Marks Jr, E. F. Parker, R. H. Fitzgerald Jr
        Pages 207-209
  4. Techniques for the Administration of Chemotherapy Agents by Continuous Infusion

  5. Back Matter
    Pages 243-248

About this book


The first conference on concomitant infusion chemotherapy and radia­ tion therapy was organized with the intention of bringing together some of the investigators who have tested, during the last few years, the hypo­ thesis that continuous infusion chemotherapy could modulate the cytotoxic effect of radiation therapy to the point of having a strongly additive, if not synergistic activity on certain malignant tumors. This volume represents the detailed proceedings of this conference presented in a way that offers the reader a review of the on-going re­ search in the field. We have stressed a number of subjects from basic biologic research and influence of cell kinetics to the practical methods of drug delivery systems and early clinical experiences. The rationale for this new type of combined modality therapy has been presented by some of its pioneers. Early clinical investigations as well as the preliminary data of many that have not yet completely matured have also been included. The reader should look at these data with some reser­ vations. Ultimately, these results must be confirmed by larger prospective randomized studies with proper controls before becoming accepted as the treatment of choice in locally advanced tumors.


cell influence kinetics radiation therapy tumors

Editors and affiliations

  • C. Julian Rosenthal
    • 1
  • Marvin Rotman
    • 2
  1. 1.Division of Medical OncologyState University of New York Health Science Center at BrooklynBrooklynUSA
  2. 2.Department of Radiation OncologyState University of New York Health Science Center of BrooklynBrooklynUSA

Bibliographic information