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White cells and platelets in blood transfusion

Proceedings of the Eleventh Annual Symposium on Blood Transfusion, Groningen 1986, organized by the Red Cross Blood Bank Groningen-Drenthe

  • Cees Th. Smit Sibinga
  • Prakash C. Das
  • C. Paul Engelfriet

Part of the Developments in Hematology and Immunology book series (DIHI, volume 19)

Table of contents

  1. Front Matter
    Pages I-XIII
  2. Principles and Functional Aspects

    1. Front Matter
      Pages N1-N1
    2. J. W. ten Cate, M. H. J. van Oers
      Pages 37-42
    3. Back Matter
      Pages 43-46
  3. Clinical Aspects

    1. Front Matter
      Pages N3-N3
    2. Presence of cells

    3. Absence of cells

    4. Back Matter
      Pages 143-146
  4. Production Aspects

    1. Front Matter
      Pages N7-N7
    2. M. K. Elias, H. Pol, M. Weggemans, A. Maas, P. C. Das, C. Th. Smit Sibinga
      Pages 163-174
    3. B. Brozovic
      Pages 199-205
    4. M. Körbling, W. Hunstein, H. Martin, R. Haas, P. Reichardt
      Pages 207-223
    5. M. K. Brenner, J.-P. Grob, H. G. Prentice
      Pages 225-236
    6. Back Matter
      Pages 237-241
  5. Laboratory Aspects

    1. Front Matter
      Pages N9-N9
    2. J. W. Smit, J. T. M. de Wolf, M. T. Esselink, M. J. A. van Luyn, N. R. Blom, T. Cazemier et al.
      Pages 249-260
    3. A. E. G. Kr. von dem Borne, W. H. Ouwehand, C. M. van Dalen
      Pages 261-267
    4. F. Rey, F. Barre-Sinoussi, J. C. Chermann
      Pages 273-280
    5. Back Matter
      Pages 281-283

About this book

Introduction

As a clinical discipline blood transfusion encompasses enormous vista, vary­ ing from biotechnology to molecular biology, from plasma products, cell biology and growth factors to interleukines. Growth of knowledge in this field has been rapid, and expertise is now required to be mastered and renewed in translating these ideas for patient care. Various types of cells could be harvested - progenitor stem cells derived from bone marrow or from circulating blood as a source for transplants; in the hemostatic armoury platelets could be used prophylactically; granulocytes and mononuclear cells are available for treatment of infections or immune modulations. However, their therapeutic use carries potential complications including graft versus host disease and CMV-infection. Prevention of such complications by irradiation and by removal of immunocompetent leukocytes are important issues. Thus, production of such therapeutic materials ought to address the issues at the earliest, to eliminate those problems while adhering to the con­ cept of high quality; the impact of storing platelets for longer periods by using improved plastic containers or storing almost indefinitely in frozen state should be explored. Rapid progress in cell culture techniques and bio­ technology have enriched the transfusion medicine armoury with lympho­ kines, interferons and cell colony growth factors which have great potentials for enhancement of basic knowledge as well as considerable therapeutic applications in patients.

Keywords

AIDS antigen bacteria growth factor infection infections

Editors and affiliations

  • Cees Th. Smit Sibinga
    • 1
  • Prakash C. Das
    • 1
  • C. Paul Engelfriet
    • 2
  1. 1.Red Cross Blood Bank Groningen-DrentheThe Netherlands
  2. 2.Central Laboratory of the Netherlands Red CrossAmsterdamThe Netherlands

Bibliographic information