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Molecular Aspects of Papovaviruses

  • Yosef Aloni

Part of the Developments in Molecular Virology book series (DMVI, volume 9)

Table of contents

  1. Front Matter
    Pages i-xv
  2. William R. Folk, W. J. Tang, M. Martin, J. Lednicky, S. Berger, R. H. Adams
    Pages 41-51
  3. M. Zenke, A. Wildeman, P. Chambon
    Pages 53-83
  4. J. Piette, M.-H. Kryszke, M. Yaniv
    Pages 85-100
  5. Lisa C. Ryner, Murari Chaudhuri, James L. Manley
    Pages 101-118
  6. J. Brady, M. Loeken, M. A. Thompson, J. Duvall, G. Khoury
    Pages 119-135
  7. F. G. Kern, P. Delli-Bovi, S. Pellegrini, C. Basilico
    Pages 137-161
  8. Susan Carswell, James C. Alwine
    Pages 185-198
  9. Walter A. Scott
    Pages 199-217
  10. Veronica Blasquez, Christine Ambrose, Henry Lowman, Minou Bina
    Pages 219-237
  11. H. Pfister, E. Kleiner, G. Lang, G. Sagner, W. Dietrich, P. G. Fuchs
    Pages 269-288
  12. Back Matter
    Pages 289-293

About this book

Introduction

It is almost twenty years since the first DNA tumor virus meeting was held at Cold Spring Harbor. At this meeting studies on three tumor viruses were discussed: the papovaviruses, the adenoviruses and the herpesviruses. The present series Developments in Molecular Virology chose to reverse this sequence by first publishing books on the herpesviruses, followed by adenoviruses, and only now the papo­ vaviruses. All the DNA tumor viruses gained their original reputation by serving as model systems in animal cells for studying gene expression and gene regulation, but SV40 and polyoma have been the jewel in the crown in these studies, as A phage was for the study of prokaryotes. SV40 was the first DNA tumor virus to be completely sequenced that enabled the definition of the cis controlling elements in DNA replication and transcription. I am continuously fascinated by the organization of the SV40 and polyoma genomes. Although they contain about 5000 bp that encode for only 6 to 7 proteins, the mechanisms which regulated their gene expression are varied and include almost any other type of gene regulation found today to regulate eukaryotic genes. Just to mention two: (i) the early promoter is a classical promoter that contains the TAT A, CAAT and enhancer elements, while the late promoter is devoid of these elements, and (ii) the mRNA can be structurally and functionally monocistronic or dicistronic. This hints at the versatility in the control of gene expression at the transcriptional and translational levels.

Keywords

antigen gene gene expression gene regulation molecular biology virology virus

Editors and affiliations

  • Yosef Aloni
    • 1
  1. 1.The Weizmann Institute of ScienceRehovotIsrael

Bibliographic information