The Stressed Heart

  • Marianne J. Legato

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 62)

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Jean Marie Moalic, Bernard Swynghedauw
    Pages 1-19
  3. Graeme L. Hammond
    Pages 21-47
  4. Robert J. Tomanek, Craig A. Canby
    Pages 49-65
  5. William M. Chilian, Robert J. Tomanek, Melvin L. Marcus
    Pages 87-105
  6. Karel Rakusan
    Pages 107-123
  7. Louis A. Sordahl, Claude R. Benedict
    Pages 149-168
  8. Anthony P. Goldman, Morris N. Kotler
    Pages 289-310
  9. Robert J. Tomanek
    Pages 311-321
  10. Edward M. Dwyer Jr.
    Pages 323-335
  11. Back Matter
    Pages 337-339

About this book


The Stressed Heart is truly unique in concept and will provide an eXCItmg adventure to the reader no matter what his or her field of expertise and interest. The title, although quite appropriate, does not adequately indicate the range of topics considered or the rational interrelationships among them. Indeed, perhaps the most important point to be learned from the book is that a serious consideration of the response of the heart to mechanical overload, ischemia, or excessive humoral stimuli must include evaluation of each of the topics in the table of contents. The heart responds to stress through alterations in both structure and function. How these changes are brought about is the subject of the initial chapters. These consider first the normal regulation of gene expression in the heart, the rapid response to mechanical overload that leads to both quantitative and qualitative changes in the contractile proteins, and our current understand­ ing of the signals that might be elicited by stress and alter gene expression. One chapter emphasizes the fact that, regardless of the nature of the stress, the common denominator is a discrepancy between energy requirements and expenditure. The central role of cellular acidosis in initiating the sequence of responses to stress and the possible roles of peptide regulators of transcription and protein regulators of translation are considered in detail.


biochemistry circulation coronary artery disease heart pathophysiology physiology tissue

Editors and affiliations

  • Marianne J. Legato
    • 1
  1. 1.Columbia University College of Physicians and SurgeonsUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1987
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-9214-2
  • Online ISBN 978-1-4613-2041-8
  • Series Print ISSN 0166-9842
  • Buy this book on publisher's site