Alterations in the Neuronal Cytoskeleton in Alzheimer Disease

  • George Perry

Part of the Advances in Behavioral Biology book series (ABBI, volume 34)

Table of contents

  1. Front Matter
    Pages i-x
  2. Steven S. M. Chin, Ronald K. H. Liem
    Pages 1-24
  3. Jacques Baudier, R. David Cole
    Pages 25-32
  4. Eduardo M. Castaño, Blas Frangione
    Pages 33-44
  5. Kenneth S. Kosik, Rachael Neve
    Pages 45-52
  6. George Perry, Valeria Manetto, Paul Mulvihill
    Pages 53-59
  7. Mark Ellisman, Rama Ranganathan, Thomas Deerinck, Stephen Young, Robert Terry, Suzanne Mirra
    Pages 61-73
  8. J. Metuzals, Y. Robitaille, S. Houghton, S. Gauthier, R. Leblanc
    Pages 75-95
  9. Khalid Iqbal, Inge Grundke-Iqbal, Henryk M. Wisniewski
    Pages 109-136
  10. George Perry, Valeria Manetto, Michelle Onorato, Madelyn Weiss, Paul Mulvihill, Pamela Galloway et al.
    Pages 137-149
  11. D. P. Hue, J. P. Brion, P. A. Robinson, B. H. Anderton
    Pages 151-163
  12. Nancy J. Pollock, Suzanne S. Mirra, John G. Wood
    Pages 181-189
  13. Pamela G. Galloway, George Perry
    Pages 199-210
  14. Back Matter
    Pages 211-229

About this book


The neuronal cytoskeleton is a complex structure responsive to both intrinsic and extrinsic factors. Defined populations of neurons in the brains of patients with Alzheimer and several other neurodegenerative diseases contain abnormal filamentous accumulations which share elements with the cytoskeleton. Although there is a general consensus that these abnormal filaments do contain cytoskeletal elements, much debate remains regarding which cytoskeletal elements are incorporated and whether the cytoskeletal rearrangement is primary or secondary to other cellular changes. In this book these questions are addressed in a historical perspect­ ive in light of new data that allows the reinterpretation of previously reported results. Contributions are based on many of the major tech­ niques of modern biology including biochemistry, molecular biology, electron microscopy and immunocytochemistry. In the view of the editor, this volume is being written at a time when our understanding of the cytopathology of Alzheimer disease is moving from predominantly descriptive to both analytical and mechanistic. I hope that this contribution will provide impetus to speed this transi­ tion. George Perry Cleveland, Ohio vii ACKNOWLEDGEMENT The support of the Fidia Pharmaceutic Corporation for the computer­ generated color figure on page 65 is gratefully acknowledged.


Alzheimer Parkinson biochemistry biology neurons

Editors and affiliations

  • George Perry
    • 1
  1. 1.Case Western Reserve UniversityClevelandUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1987
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-8920-3
  • Online ISBN 978-1-4613-1657-2
  • Series Print ISSN 0099-6246
  • Buy this book on publisher's site