Clinical Applications of Monoclonal Antibodies

  • Ron Hubbard
  • Vincent Marks

Table of contents

  1. Front Matter
    Pages i-x
  2. Production and Purification of Monoclonal Antibodies

    1. Front Matter
      Pages 1-1
    2. U. Zimmermann, J. J. Schmitt, P. Kleinhans
      Pages 3-19
    3. Elizabeth V. Walls, Kitty Lam, Dorothy H. Crawford
      Pages 21-32
    4. Lutz Riechmann
      Pages 33-34
  3. Monoclonal Antibodies in the Clinical Laboratory

    1. Front Matter
      Pages 35-35
    2. J. Landon, S. Akman
      Pages 37-40
    3. Roger Ekins
      Pages 41-59
    4. J. Stuart Woodhead, J. Paul Aston, Richard C. Brown, Ian Weeks
      Pages 61-68
    5. Ian Weeks, J. Stuart Woodhead
      Pages 69-79
    6. Kenneth Siddle, Maria A. Soos, Richard O’Brien, Rosalind H. Ganderton, T. S. Pillay
      Pages 87-99
    7. F. Frankenne, J. Closset, F. Gomez, G. Pirens, J. Smal, G. Hennen
      Pages 101-112
  4. Clinical and Veterinary Applications of Monoclonal Antibodies

    1. Front Matter
      Pages 113-113
    2. W. H. Wunner, B. Dietzschold, C. E. Rupprecht, H. Koprowski
      Pages 115-137
    3. David Emanuel, Joanne Peppard, Jihed Chehimi, Ulrich Hammerling, Richard O’Reilly
      Pages 139-148
    4. P. A. Bradshaw, S. Perkins, E. T. Lennette, J. Rowe, S. K. H. Foung
      Pages 149-158
    5. Colin M. M. Stern
      Pages 159-166
    6. A. R. M. Coates, P. Baird, H. Nicholai, Y. Nitzan
      Pages 167-178
    7. Judith A. Deans
      Pages 179-185
    8. D. J. Groves, B. A. Morris
      Pages 187-197
    9. R. E. Spier, D. Langley
      Pages 199-206
    10. Edgar Haber, Marschall S. Runge, Christoph Bode, Elizabeth E. Branscomb, Janet M. Schnee, Thomas Quertermous et al.
      Pages 207-213
  5. Antibodies in Tumour Diagnosis and Therapy

    1. Front Matter
      Pages 215-215
    2. A. R. Bradwell, P. W. Dykes, A. T. M. Vaughan
      Pages 245-251
  6. Back Matter
    Pages 253-258

About this book


Immunology has come a long way in the hundred or so years since the general concepts were first enuciated by Metchnikoff, Ehrlich, Von Bebring and others, One of the landmarks in this progress was the invention and development of monoclonal antibody secreting hybridomas by Milstein and bis co-workers in Cambridge. Unlike most modern inventions of this importance that of monoclonal antibody production was made available to the scientific community tbroughout the world unimpeded by patent protection. This may explain tbe unusual rapidity witb which it has been applied to the benefit of mankind in general. This book, representing as it does the proceedings of tbe first International Symposium to be held on the clinical appli­ cations of monoclonal antibodies, shows just how much bas been achieved within the space of little more than a decade. The enormaus promise of monoclonal antibody technology, which became apparent soon after its discovery, has already progressed a long way towards fulfillment. The contributors to tbis volume, all of whom are actively engaged in monoclonal antibody development and application, represent the state of the art. Professor Vincent Marks V INTRODUCTION It has been some twelve years since the pioneering experiments of Köhler and Milstein led to the discovery of monoclonal antibodies. Single molecular species antiborlies with desired specificities could be produced by the fusion of antibody - producing cells with neoplastic cells.


antibody antibody production cells clinical application development immunology production

Editors and affiliations

  • Ron Hubbard
    • 1
  • Vincent Marks
    • 1
  1. 1.University of SurreyGuildford, SurreyUK

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