Subcellular Basis of Contractile Failure

Proceedings of the Symposium Sponsored by the Council of Cardiac Metabolism, International Society and Federation of Cardiology and International Society for Heart Research, May 11–13, 1989, Ottawa, Canada

  • Editors
  • Borivoj Korecky
  • Naranjan S. Dhalla

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 116)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Role of Cations in Heart Function

    1. Front Matter
      Pages 1-1
    2. T. Asai, H. Terada, Y. M. Shuba, T. F. McDonald, D. Pelzer
      Pages 19-37
    3. Rodolphe Fischmeister, Pierre-François Mery, Alvin Shrier, Catherine Pavoine, Véronique Brechler, Françoise Pecker
      Pages 39-54
    4. F. Scamps, E. Mayoux, D. Charlemagne, G. Vassort
      Pages 55-67
    5. G. N. Pierce, T. G. Maddaford
      Pages 85-96
    6. J. C. Khatter, S. Navaratnam, M. Agbanyo
      Pages 97-111
  3. Cardiac Hypertrophy and Cardiomyopathies

    1. Front Matter
      Pages 113-113
    2. H. Rupp, R. Jacob, N. S. Dhalla
      Pages 135-154
    3. Michael J. Daly, Enn K. Seppet, Roland Vetter, Naranjan S. Dhalla
      Pages 173-191
    4. M. Kato, N. Takeda, A. Takeda, T. Ohkubo, M. Nagai, M. Nagano
      Pages 193-208
    5. N. Takeda, T. Okubo, T. Iwai, A. Tanamura, M. Nagano
      Pages 209-217
    6. C. Ou, S. Majumder, J. Dai, V. Panagia, N. S. Dhalla, R. Ferrari
      Pages 219-234
  4. Ischemic Heart Disease and Cardiac Failure

    1. Front Matter
      Pages 235-235
    2. J. M. J. Lamers, L. M. A. Sassen, J. M. Hartog, C. Guarnieri, P. D. Verdouw
      Pages 237-256
    3. R. Ferrari, S. Curello, C. Ceconi, E. Pasini, A. Cargnoni, A. Albertini et al.
      Pages 257-271
    4. W. B. Weglicki, B. F. Dickens, J. H. Kramer, I. T. Mak
      Pages 273-284
    5. P. K. Singal, L. A. Kirshenbaum, M. Gupta, A. K. Randhawa
      Pages 305-320

About this book


This monograph contains 20 selected papers presented at the Symposium on Subcellular Basis of Contractile Failure which was held in Ottawa during May 11-13, 1989 and is designed for the benefit ofthose who were unable to attend this event. It is now increasingly becoming clear that an excessive amount of calcium is intimately involved in the pathogenesis of a wide variety of heart diseases. Accordingly, the investigations concerning the role of calcium chan­ nels and their regulatory mechanisms in heart function as well as of the intra­ cellular calcium overload in cardiac dysfunction are presented here. Since sodium is also considered to influence the cardiac contractile force by chang­ 2 ing the intracellular concentration of calcium through the Na +-Ca+ exchange 2 mechanism in the cell membrane, the role of Na +-Ca+ exchange in heart func­ tion as well as pathology of contractile failure is discussed. In view of the new­ ly discovered implications of the oxygen free radicals in cellular injury, papers concerning the role of these radicals in heart disease are included in this book. For the purpose of clarity, different chapters have been organized under three main headings: (I) Role of cations in heart function, (II) Cardiac hypertrophy and cardiomyopathies, and (III) Ischemic heart disease and cardiac failure.


cardiology cardiovascular heart heart disease

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1990
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-8813-8
  • Online ISBN 978-1-4613-1513-1
  • Series Print ISSN 0166-9842
  • Buy this book on publisher's site