Controlled Clinical Trials in Neurological Disease

  • Roger J. Porter
  • Bruce S. Schoenberg

Part of the Foundations of Neurology book series (FONY, volume 1)

Table of contents

  1. Front Matter
    Pages i-xxiii
  2. Design of Controlled Clinical Trials

    1. Front Matter
      Pages 1-1
    2. John F. Kurtzke
      Pages 3-16
    3. B. G. White
      Pages 17-27
    4. James M. Dambrosia
      Pages 29-51
  3. Implementation and Interpretations of Controlled Clinical Trials (Example: Epilepsy)

    1. Front Matter
      Pages 53-53
    2. Nancy Santilli
      Pages 55-62
    3. Fritz E. Dreifuss, Nancy Santilli
      Pages 63-68
    4. Nancy Santilli
      Pages 69-76
    5. James J. Cereghino
      Pages 77-83
    6. Lynn D. Kramer, James L. Perhach
      Pages 97-104
    7. Lawrence C. Morris
      Pages 105-110
  4. Applications of Controlled Clinical Trials to Diseases of the Nervous System

    1. Front Matter
      Pages 111-111
    2. Michel A. Beaudry, Vladimir C. Hachinski
      Pages 113-132
    3. Roger J. Porter
      Pages 133-155
    4. Lawrence I. Golbe, Roger C. Duvoisin
      Pages 157-170
    5. Howard M. Eisenberg
      Pages 171-183
    6. Jes Olesen, Peer Tfelt-Hansen
      Pages 185-201
    7. Peter James Dyck, Peter O’brien
      Pages 203-224
    8. E. David Mellits, Guy M. McKhann
      Pages 225-247
    9. Benjamin Rix Brooks, Roxanne Depaul, Yan De Tan, Mohammed Sanjak, Robert L. Sufit, Joanne Robbins
      Pages 249-281
    10. Richard S. A. Tindall
      Pages 283-304
    11. Gerald M. Fenichel, Michael H. Brooke
      Pages 305-319
    12. Henry F. McFarland
      Pages 321-341
    13. Mark G. Malkin, Jerome B. Posner
      Pages 343-360
    14. David A. Drachman, Joan M. Swearer
      Pages 361-391
    15. Michael Schlitt, Richard J. Whitley
      Pages 393-406
    16. Gustavo C. Román
      Pages 407-424
  5. Back Matter
    Pages 425-440

About this book


The evaluation of the efficacy and safety of a clinical tool, be it a diagnostic technique, a preventive methodology, or a therapeutic intervention, is an im­ portant responsibility of physicians. The history of medicine is characterized by the authoritarianisms of teachers and of organizations giving way to the clinical experience of physicians; authoritarian dictum was replaced by case report and then by case series. As physicians learned to substitute the analysis of data for the inconsistencies of dictums and anecdotes, the problems of the case series as an investigative tool became more evident: patient selection criteria, measurements of outcome, significance of results, and extrapolation of conclusions to the community of patients. In response to these issues, the methodology of the controlled clinical trial has evolved and with it the instru­ ments of study design and of biostatistics as aids to study design and data analysis. The medical - surgical armamentarium has evolved from being dependent solely upon the observations and conclusions of a skilled clinician to being constructed upon the systematic collection and evaluation of data by a team of skilled clinicians and their statistical colleagues: this is the controlled clinical trial. During the past two decades, the evaluation of clinical approaches to pre­ vention and therapy has become particularly important to clinicians concerned with nervous system dysfunction. There has been and continues to be an explosion of information from the basic neurosciences and from the applica­ tion of biotechnology to the nervous system.


Alzheimer Nervous System alzheimer's disease brain brain tumor neuroscience spinal cord tumor

Editors and affiliations

  • Roger J. Porter
    • 1
  • Bruce S. Schoenberg
    • 1
  1. 1.National Institute of Neurological Disorders and StrokeNational Institutes of HealthBethesdaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1990
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-8804-6
  • Online ISBN 978-1-4613-1495-0
  • Series Print ISSN 0924-8935
  • Buy this book on publisher's site