The Heart in Diabetes

  • John C. Chatham
  • John R. Forder
  • John H. McNeill

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 185)

Table of contents

  1. Front Matter
    Pages i-x
  2. Alain Borczuk, Stephen M. Factor
    Pages 23-40
  3. Makilzhan Shanmugam, Louis Arroyo, Abbas Shehadeh, Timothy J. Regan
    Pages 41-65
  4. John H. McNeill, Brian Rodrigues
    Pages 66-84
  5. David L. Geenen, Ashwani Malhotra
    Pages 85-99
  6. Naranjan S. Dhalla, Leonard S. Golfman, Vijayan Elimban, Nobuakira Takeda
    Pages 100-142
  7. John R. Forder
    Pages 143-165
  8. Maren R. Laughlin
    Pages 166-188
  9. John C. Chatham
    Pages 189-214
  10. John C. Chatham, John R. Forder, John H. McNeill
    Pages 252-259
  11. Back Matter
    Pages 260-267

About this book


Diabetes is a major public health problem which is expected to affect 160 million people worldwide by the year 2000. Clearly an understanding of the effects of diabetes on the heart is an important step in the development of strategies to reduce the incidence of heart disease for diabetic patients, thus increasing their overall life-expectancy and quality of life.
In this book, the editors bring together the different lines of evidence supportive of the idea of a diabetic cardiomyopathy. The first chapter provides an overview of the impact of cardiac dysfunction on the mortality and morbidity of the diabetic population in general, as well as a presentation of clinical aspects of heart disease in diabetes. This is followed by chapters concerned with the pathological and functional changes that occur in the heart as a result of diabetes and a description of the various therapeutic interventions that are available to reverse the effects of diabetes on the heart. Subsequent chapters focus on changes in protein synthesis, membrane function and intermediary metabolism that take place following the onset of diabetes. Since these alterations precede many of the functional and pathological changes, it may be that the processes responsible for the functional decline and tissue injury are initiated by diabetes-induced changes at the cellular and/or biochemical level.


Diabetes Diabetes mellitus cardiac function heart metabolism protein

Editors and affiliations

  • John C. Chatham
    • 1
  • John R. Forder
    • 1
  • John H. McNeill
    • 2
    • 3
  1. 1.Department of Radiology, Division of NMR ResearchJohns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Faculty of Pharmaceutical SciencesUniversity of British ColumbiaVancouverCanada
  3. 3.Faculty of Pharmaceutical SciencesUniversity of British ColumbiaVancouverCanada

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1996
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-8541-0
  • Online ISBN 978-1-4613-1269-7
  • Series Print ISSN 0166-9842
  • Buy this book on publisher's site