Basic and Clinical Applications of Flow Cytometry

Proceeding of the 24th Annual Detroit Cancer Symposium Detroit, Michigan, USA - April 30, May 1 and 2, 1992

  • Frederick A. Valeriote
  • Alexander Nakeff
  • Manuel Valdivieso

Part of the Developments in Oncology book series (DION, volume 77)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Alexander Nakeff
    Pages 1-3
  3. Daniel W. Visscher, Susan M. Wykes, John D. Crissman
    Pages 13-32
  4. Awtar Krishan, Cheppail Ramachandran, Antonieta Sauerteig
    Pages 49-64
  5. Charles L. Hitchcock, John F. Ensley, Mark Zalupski
    Pages 95-123
  6. M. Cankovic, T. Wrone-Smith, E. VanBuren, S. Lerman
    Pages 125-142
  7. Mario Roederer, Leonard A. Herzenberg
    Pages 197-210
  8. Alexander Nakeff
    Pages 239-250

About this book


The focus of this symposium was on the present and future capabilities of flow cytometry for both medical and biological applications in cancer. This technology began with quite modest instrumentation, with limited capabilities to answer biological questions. Today, both the clinical workhorses and the powerful multi-laser, multi-detector, sorting machinery, coupled with sophisticated computers and storage devices and the increasing storehouse of markers and dyes, are taking us to the limit and beyond in finding answers to the cause and cure of cancer.
In the past, both normal hematopoietic tissue and leukemias have been the tissue samples of choice in the application of flow cytometry, and some of the most recent applications with these tissues are presented here. However, the book also discusses the increasingly sophisticated disaggregation techniques which allow investigators the possibility to train their lasers on solid tumors. Not only can we use flow cytometry with associated fluorescent markers to understand the biology of cancer, but also the wide array of existing and developing markers provides us with important diagnostic tools in the detection of cancer early in either the malignant or relapse process. And the field comes full circle, with the use of the technology for gene mapping and other genetic studies to unlock the basic malignant process.


DNA cell clinical trial cytogenetics genetics laser leukemia lymphoma transplantation

Editors and affiliations

  • Frederick A. Valeriote
    • 1
  • Alexander Nakeff
    • 1
  • Manuel Valdivieso
    • 1
  1. 1.Division of Hematology and Oncology, School of MedicineWayne State UniversityDetroitUSA

Bibliographic information