Molecular Neurobiology of the Olfactory System

Molecular, Membranous, and Cytological Studies

  • Frank L. Margolis
  • Thomas V. Getchell

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Transduction and Ligand-Receptor Interactions

    1. Front Matter
      Pages 1-1
    2. Solomon H. Snyder, Pamela B. Sklar, Jonathan Pevsner
      Pages 3-24
    3. Marilyn L. Getchell, Barbara Zielinski, Thomas V. Getchell
      Pages 71-98
    4. Valina L. Dawson, Ted M. Dawson, James K. Wamsley
      Pages 99-117
  3. Molecular Biophysics and Membrane Function

    1. Front Matter
      Pages 119-119
    2. Randall B. Murphy
      Pages 121-142
    3. Robert A. Maue, Vincent E. Dionne
      Pages 143-158
    4. John A. DeSimone, Krishna C. Persaud, Gerard L. Heck
      Pages 159-181
  4. Biochemical-Molecular Biological Studies

    1. Front Matter
      Pages 183-183
    2. Dieter G. Weiss, Klaus Buchner
      Pages 217-236
  5. Development and Differentiation

    1. Front Matter
      Pages 267-267
    2. Richard A. Akeson
      Pages 297-318
    3. Peter C. Barber, Steen Jensen
      Pages 333-352
  6. Biological Relevance of Olfactory Function

    1. Front Matter
      Pages 353-353
    2. Richard L. Doty, James B. Snow Jr.
      Pages 355-374
  7. Back Matter
    Pages 375-379

About this book


The sense of smell and the olfactory system have been a subject of intrinsic interest for millenia. Inquiry into the structure and function of the olfactory system is based on a long tradition that dates back at least to the ancient Greeks. The mechanistic basis for the sensitivity and selectivity of this chemosensory detection system has always posed a challenge and remained largely a mystery. Recently, there has been a renaissance of interest in it and especially in the application of contemporary techniques of biochemistry and cellular and molecular biology. In this volume, current research utilizing these ap­ proaches is discussed in depth by a group of scientists who are among the current leaders in the applications of these techniques to the olfactory system. These authors address a wide range of questions that bear directly on the olfactory system but have broader biological implications as well. The various chapters have been grouped into five broad subject areas that emphasize diverse but related questions. "Transduction and Ligand-Receptor Interactions" considers the biochemical bases of stimulus access, interaction, transduction, elimination, and information processing.


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Editors and affiliations

  • Frank L. Margolis
    • 1
  • Thomas V. Getchell
    • 2
  1. 1.Roche Institute of Molecular BiologyNutleyUSA
  2. 2.Wayne State University School of MedicineDetroitUSA

Bibliographic information