Recent Advances in Nervous System Toxicology

  • Corrado L. Galli
  • Luigi Manzo
  • Peter S. Spencer
Conference proceedings

Part of the NATO ASI Series book series (NSSA, volume 100)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Neurotoxic Effects of Prolonged Exposure to Toxic Agents

    1. Front Matter
      Pages 1-1
    2. Emilio Perucca, Luigi Manzo
      Pages 67-86
    3. Joep van den Bercken
      Pages 87-89
    4. Joep van den Bercken, Henk P. M. Vijverberg
      Pages 91-105
    5. Edith G. McGeer, Patrick L. McGeer
      Pages 107-131
    6. W. Meier-Ruge
      Pages 133-159
  3. Neurotoxic Agents in the Human Environment

    1. Front Matter
      Pages 161-161
    2. Peter S. Spencer, Herbert H. Schaumburg
      Pages 163-176
    3. Lucio G. Costa
      Pages 203-246
    4. S. Govoni, F. Battaini, R. A. Rius, C. Fernicola, L. Coniglio, M. Trabucchi
      Pages 259-275
  4. Experimental Models and Assessment of Neurotoxic Mechanisms

    1. Front Matter
      Pages 277-277
    2. Vincenzo Cuomo, Giorgio Racagni
      Pages 297-305
    3. Lucio G. Costa, Marina Marinovich, Corrado L. Galli
      Pages 307-349
  5. Back Matter
    Pages 377-391

About these proceedings


This volume addresses some facets of the adverse actions of chemical agents on the central and peripheral nervous systems in developing and mature states. Some of the effects of these chemicals are short-lasting and rapidly reversible; others, especially those that cause structural damage to the nervous system, may result in permanent damage to the organism. The nervous system has several levels of vulnerability to toxic substances. Some substances perturb ion channels or synaptic mechanisms required for the orderly transfer of electrochemical information within the nervous system. Others disrupt sites required for the maintenance of cellular integrity, and these variably result in degenerative responses of neurons and myelinating cells. Further sites of vulnerability include the delicate neural vasculature and neurohumeral mechanisms responsible for physiological homeostasis. The science of neurotoxicology inevitably is a multidisciplinary endeavor, with contributions from biochemistry, physiology, morphology and behavior, to name a few. The challenge is to apply appropriate techniques to investigate neurotoxic phenomena. The first logical step in this analysis is to determine from the point of view of the nervous system the nature of the exposure. Is the chemical a single or multiple entity; is it metabolized; how does it gain access to neural tissue? Once these factors are understood, changes induced by the exposure can be described at various levels from the biochemical to the behavioral.


Nervous System biochemistry neurobehavioral assessment neurons neurotoxicology physiology

Editors and affiliations

  • Corrado L. Galli
    • 1
  • Luigi Manzo
    • 2
  • Peter S. Spencer
    • 3
  1. 1.Institute of Pharmacology and PharmacognosyMilanItaly
  2. 2.Institute of PharmacologyPaviaItaly
  3. 3.Albert Einstein College of Medicine of Yeshiva UniversityBronxUSA

Bibliographic information