Guanidines 2

Further Explorations of the Biological and Clinical Significance of Guanidino Compounds

  • Akitane Mori
  • Burton D. Cohen
  • Hikaru Koide

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Analytical Method for Guanidino Compounds and New Guanidino Compounds

    1. Front Matter
      Pages 1-1
    2. Moto-o Nakajima, Kazuo Nakamura, Yoshio Shirokane, Yoshihei Hirasawa
      Pages 3-11
    3. Katsuo Haruki, Shuichi Hatakeyama, Masayoshi Hirata, Hiroaki Muramoto, Yohei Tofuku, Ryoyu Takeda
      Pages 13-14
  3. Metabolism of Guanidino Compounds

    1. Front Matter
      Pages 33-33
    2. Ijaz A. Qureshi, Bart Marescau, Maurice Levy, Peter P. De Deyn, Jacques Letarte, Armand Lowenthal
      Pages 45-51
    3. Yoko Watanabe, Isao Yokoi, Akitane Mori
      Pages 53-60
    4. Myron D. Gross, Alexander M. Simon, Richard J. Jenny, Ernest D. Gray, Denise M. McGuire, John F. Van Pilsum
      Pages 61-69
    5. Kazumasa Aoyagi, Sohji Nagase, Masako Sakamoto, Mitsuharu Narita, Shizuo Tojo
      Pages 79-85
    6. Masako Sakamoto, Kazumasa Aoyagi, Sohji Nagase, Shoji Ohba, Mitsuhiro Miyazaki, Mitsuharu Narita et al.
      Pages 87-95
    7. Midori Hiramatsu, Rei Edamatsu, Masahiro Kohno, Akitane Mori
      Pages 97-105
  4. Physiological, Pharmacological and Toxicological Aspects of Guanidino Compounds

    1. Front Matter
      Pages 107-107
    2. Burton D. Cohen
      Pages 109-113
    3. Katsuya Nagai, Akiko Hashida, Hachiro Nakagawa
      Pages 115-122
    4. Michio Kitaura, Yoji Ochiai, Seiji Sugimoto, Koji Kabutan, Yoshinori Kosogabe, Chiaki Tsuji et al.
      Pages 129-134

About this book

Introduction

Guanidine is named for its similarity to the purine guanine which, in turn, is named for its principal source guano, which comes from the Inca word, huano, for dung. Guanidine, therefore, translates into dung-like, which is hardly a genteel way to introduce a subject. On the other hand, texts are seldom inspirational, "frequently crude and rarely literary and should be judged on how successfully they assemble, organize and present current data. I am impressed that the material which fol]ows goes a long way toward successfully achieving those goals. Tue International Guanidine Society is a synthesis of three groups of investigators: biologists studying guanidines as phosphagens, neurologists interested in guanidines as convulsants and nephrologists involved with guanidines as toxins. As a member of the latter group. I am gratified by the considerable progress this book represents. To begin with. there now appears to be a common theme which unifies current speculation concerning the metabolic origin of the guanidines in uremia. At the First International Congress in 1983, evidence was presented which supported the theory that certain guanidines were products of the mixed function oxidation of urea. This year's meeting brings together overwhelming data showing that methyl guanidine is an effect of active oxygen reacting with creatinine. An idolatry, worshipped throughout biochemistry, that urea and creatinine are inert byproducts of protein metabolism, is shown to have feet of clay.

Keywords

Oxidation Toxin biochemistry chemistry plants

Editors and affiliations

  • Akitane Mori
    • 1
  • Burton D. Cohen
    • 2
  • Hikaru Koide
    • 3
  1. 1.Okayama University Medical SchoolOkayamaJapan
  2. 2.The Bronx Lebanon Hospital CenterBronxUSA
  3. 3.Juntendo University School of MedicineTokyoJapan

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4613-0821-8
  • Copyright Information Springer-Verlag US 1989
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-8099-6
  • Online ISBN 978-1-4613-0821-8
  • About this book