Trends in Neuroimmunology

  • Maria Giovanna Marrosu
  • Carlo Cianchetti
  • Bruno Tavolato

Table of contents

  1. Front Matter
    Pages i-viii
  2. Humoral Immunologic Studies in Cerebrospinal Fluid

    1. Front Matter
      Pages 1-1
    2. A. De Rossi, P. Gallo, A. Amadori, M. G. Piccinno, A. Del Mistro, S. Pagni et al.
      Pages 13-22
    3. Paolo Livrea, Maria Trojano, Isabella Laura Simone, Carlo Avolio, Francesca De Robertis, Brigida Coluccia et al.
      Pages 23-31
    4. P. Gallo, K. Frei, D. Leppert, A. Fontana
      Pages 33-39
  3. Cell Studies

    1. Front Matter
      Pages 41-41
    2. H. Link, S. Baig, Y.-P. Jiang, O. Olsson, B. Höjeberg, V. Kostulas et al.
      Pages 43-50
    3. V. Jewtoukoff, M. A. Bach
      Pages 51-57
    4. V. Barnaba, R. Benvenuto, C. Buttinelli, A. Franco, S. Bernardi, M. G. Grasso et al.
      Pages 67-70
    5. V. L. Calder, S. J. Owen, A. N. Davison
      Pages 71-74
  4. Immune Functions of Glia

    1. Front Matter
      Pages 75-75
    2. A. Fontana, K. Frei, P. Gallo, T. P. Leist, D. Leppert, U. V. Malipiero et al.
      Pages 77-86
    3. M. G. Ennas, S. Torelli, V. Sogos, C. Marcello, A. Riva, F. Gremo
      Pages 87-96
    4. L. Massacesi, A. L. Abbamondi, F. Sarlo, E. Castigli, J. Olivotto, M. Vergelli et al.
      Pages 97-102
    5. M. G. Marrosu, M. G. Ennas, S. Torelli, V. Sogos, P. Puligheddu, U. Lecca et al.
      Pages 103-109
    6. Christine D. Dijkstra, C. H. Polman, A. Kreike, C. J. A. De Groot, J. C. Koetsier, T. Sminia
      Pages 111-115
  5. Central Nervous System Diseases and the Immune System

    1. Front Matter
      Pages 117-117
    2. Peter Schmid, Andrew Conrad, Diethart Schmid, Wallace W. Tourtellotte
      Pages 119-125
    3. Carlo Cianchetti, Francesco Muntoni, Annalisa Fratta, Maria Giovanna Marrosu
      Pages 127-134
    4. Patrizia Casaccia, Anna Ladogana, Carlo Masullo, Giorgio Macchi, Maurizio Pocchiari
      Pages 135-149
    5. G. B. Zimatore, G. Angarano, I. L. Simone, S. Carbonara, C. Casalino, B. Coluccia et al.
      Pages 151-156
  6. Back Matter
    Pages 165-169

About this book


Immunology has developed quite impressively over the past decade and perhaps very few fields in medicine or biology have grown so explosively. Completely new fields have been elucidated in depth. We recall only the definition of the nature and function of RLA antigens at the molecular level. the chemical and functional identification of several cytokines. and the correlation to particular immunological functions of specific epitopes present on cellular mem­ branes. The extensive application of immunological techniques and concepts to the neurological sciences has led to the development of neuroimmunology. a disci­ pline in its infancy until few years ago. In these last years. neuroimmunology has developed researches in various fields. RLA antigens were studied at the cellular level in brain samples and in CSF cells in several diseases. Cytokines. such as interleukin 1 and 2. gamma- and alpha-interferons. and tumor necrosis factor alpha. were studied at the immunohistological level and with quantitative methods in serum and CSF. With these data. new relevant insights were obtained on the molecular mechanisms underlying CNS immunological diseases. Moreover. neuroimmunological researches were carried on through the development of new and more 'specific' technologies for the study of natural and experimental diseases. the most important of which seem to be. at present. the techniques of cell cultures for cell lines specific to the CNS (oligodendrocytes. astroglia. microglia. meningeal cells. brain capillary cells and tumor cells).


Antigen blood cytokine diseases immunodeficiency immunoglobulin infection infections interferon necrosis pathogenesis virus

Editors and affiliations

  • Maria Giovanna Marrosu
    • 1
  • Carlo Cianchetti
    • 1
  • Bruno Tavolato
    • 2
  1. 1.University of CagliariCagliariItaly
  2. 2.University of PaduaPaduaItaly

Bibliographic information