Myocardial Protection and the KATP Channel

  • Derek M. Yellon
  • Garrett J. Gross

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 179)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Nicholas B. Standen
    Pages 1-30
  3. Ulrich Quast, Stefan Glocker
    Pages 31-50
  4. Garret J. Gross, Derek M. Yellon
    Pages 99-120
  5. Michiel J. Janse, Arthur A. M. Wilde
    Pages 121-139
  6. Henry Purcell, Kim Fox
    Pages 141-159
  7. Back Matter
    Pages 209-214

About this book


The ATP-sensitive potassium channel (KATP) was discovered in 1983. Since then, an enormous amount of research has been undertaken to characterize it in detail. This volume consolidates both the current knowledge and most recent advances on the subject, and its relationship to myocardial protection. To this end, the editors have assembled investigators at the forefront of ongoing basic and clinical research to provide scholarly and candid comments concerning each of the pertinent issues, including: a comprehensive review of the biology of the channel with respect to the structure-activity relationship as well as overall chemistry of the channel; the role of opening this channel and its effect on smooth muscle (covering both the effects on myocardial stunning and its ability to protect against myocardial infarction); the relationship of KATP channel opening and the protection to the myocardium afforded by the phenomenon of ischemic preconditioning; the relationship between the KATP channel and electrophysiological consequences with specific reference to arrhythmogenicity; and the clinical implications of the use of agents that mimic the opening of this channel, with reference to its protective nature and its use in the treatment of angina.
Audience: Clinicians and basic scientists who have a direct interest in the KATP channel as well as those groups who are interested in the entire concept of myocardial protection and its relationship to academic and clinical medicine.


biology chemistry clinical research medicine muscle myocardial infarction pathology pharmacology research treatment

Editors and affiliations

  • Derek M. Yellon
    • 1
  • Garrett J. Gross
    • 2
  1. 1.University College London Medical School & HospitalsLondonUK
  2. 2.Department of Pharmacology & ToxicologyMedical College of WisconsinMilwaukeeUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1995
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-8055-9
  • Online ISBN 978-1-4613-0453-1
  • Series Print ISSN 0166-9842
  • Buy this book on publisher's site