NMR as a Structural Tool for Macromolecules

Current Status and Future Directions

  • B. D. Nageswara Rao
  • Marvin D. Kemple

Table of contents

  1. Front Matter
    Pages i-x
  2. B. D. Nageswara Rao
    Pages 1-13
  3. R. R. Ernst, M. J. Blackledge, T. Bremi, R. Brüschweiler, M. Ernst, C. Griesinger et al.
    Pages 15-30
  4. Julie D. Forman-Kay, Steven M. Pascal, Alex U. Singer, Toshio Yamazaki, Ouwen Zhang, Neil A. Farrow et al.
    Pages 35-47
  5. Gerhard Wagner, Daniel F. Wyss, Johnathan S. Choi, Antonio R. N. Arulanandam, Ellis L. Reinherz, Andrzej Krezel et al.
    Pages 51-62
  6. David Case, Marvin D. Kemple, N. Rama Krishna, Carol B. Post, Gerhard Wagner
    Pages 103-116
  7. Stephan Grzesiek, Geerten W. Vuister, Andy C. Wang, Frank Delaglio, Ad Bax
    Pages 117-120
  8. Sébastien J. F. Vincent, Catherine Zwahlen, Geoffrey Bodenhausen
    Pages 145-164
  9. Maurice Guéron, Kalle Gehring, Jean-Louis Leroy
    Pages 167-171
  10. R. Kaptein, M. Slijper, V. P. Chuprina, J. A. C. Rullmann, R. M. A. Knegtel, R. Boelens
    Pages 175-187
  11. Thomas L. James, Carlos González, He Liu, Uli Schmitz, Nikolai B. Ulyanov
    Pages 191-203
  12. G. Marius Clore, Stephen W. Fesik, David G. Gorenstein, David M. LeMaster, John L. Markley
    Pages 207-219
  13. S. W. Fesik, R. P. Meadows, E. T. Olejniczak, A. P. Petros, P. J. Hajduk, H. S. Yoon et al.
    Pages 221-234
  14. G. Marius Clore, Angela M. Gronenborn
    Pages 237-242
  15. Peter E. Wright, H. Jane Dyson
    Pages 245-249

About this book

Introduction

The contemplation of truth and beauty is the proper object for which we were created, which calls forth the most intense desires of the soul, and of which it never tires -Hazlitt In his Nobel lecture Purcell commented that when he saw snow in New England after the discovery of NMR, it appeared like "heaps of protons quietly precessing in earth's magnetic field. " If he were to make the comment in the context of how NMR is being used today, he could have conjured up an image of hydrogen, carbon, and nitrogen nuclei in proteins of an earthbound 8rganism subtly orchestrating a quiet symphony of frequencies, from 150 Hz to 2 kHz, carrying clues to the three-dimensional structure of the macromolecules. The manner in which the basic discoveries of Bloch and Purcell have led to the emergence of NMR, several decades later, as a major technique of biological and medical physics (and chemistry) is a striking example of the power of basic research. It is also a fascinating saga whereby whenever it was felt that the field had reached a plateau, new directions, new technologies, and sometimes serendipity produced new developments that revolutionized the technique and enhanced its capability. As Richard Ernst points out "NMR is intellectually attractive, . . . the practical importance of NMR is enormous, and can justify much of the playful activities of an addicted spectroscopist" (Nobel lecture).

Keywords

Calcium Nucleotide Peptide chemistry medical physics protein proteins spectroscopy

Editors and affiliations

  • B. D. Nageswara Rao
    • 1
  • Marvin D. Kemple
    • 1
  1. 1.Indiana University-Purdue University, Indianapolis (IUPUI)IndianapolisUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4613-0387-9
  • Copyright Information Springer-Verlag US 1996
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-8029-0
  • Online ISBN 978-1-4613-0387-9
  • About this book