Frontiers in Hypertension Research

  • John H. Laragh
  • Fritz R. Bühler
  • Donald W. Seldin
Conference proceedings

Table of contents

  1. Front Matter
    Pages i-xxxix
  2. Frontiers in Hypertension Research: Past, Present and Future Introduction

  3. The Variation in Risk Among Hypertensive Patients: Is Broad Scale Therapy to Help Only a Few Justifiable? What Pressure Levels Should Be Treated?

  4. Dietary Sodium and Human Hypertension

    1. Front Matter
      Pages 35-35
    2. Yukio Yamori, Yasuo Nara, Masahiro Kihara, Ryoichi Horie, Akira Ooshima
      Pages 46-48
    3. Richard P. Ames, Peter Hill
      Pages 49-53
    4. F. O. Simpson, Judith Paulin
      Pages 54-57
    5. Myron H. Weinberger, Friedrich C. Luft, Richard Bloch, David P. Henry, Arthur E. Weyman, Laura I. Rankin
      Pages 58-61
    6. T. Morgan, J. Myers, W. Adam
      Pages 62-68
  5. Sodium Metabolism: The Sodium-Potassium Membrane Pump and Volume Overload Hypertension

    1. Front Matter
      Pages 69-69
    2. Francis J. Haddy, Motilal B. Pamnani, David L. Clough
      Pages 71-80
    3. Ricardo P. Garay, Philippe Meyer
      Pages 81-83
    4. Mordecai P. Blaustein, Stanley Lang, Marilyn James-Kracke
      Pages 87-90
    5. G. A. MacGregor, H. E. de Wardener
      Pages 94-101
  6. Regulation of Blood Pressure by Prostaglandin-Kinin Interactions

    1. Front Matter
      Pages 103-103
    2. J. C. Frölich, D. Robertson, W. Kitajima, B. Rosenkranz, I. Reimann
      Pages 114-118
    3. Alberto Nasjletti, Kafait U. Malik
      Pages 119-121
  7. The Concept of Whole Body Autoregulation and the Dominant Role of the Kidneys for Long-Term Blood Pressure Regulation

    1. Front Matter
      Pages 123-123
    2. Arthur C. Guyton, John E. Hall, Thomas E. Lohmeier, R. Davis Manning Jr., Thomas E. Jackson
      Pages 125-134
    3. C. S. Wilcox
      Pages 135-138
    4. Gerald F. DiBona
      Pages 141-142
  8. Vasoconstriction and Volume Factors in Renovascular Hypertension

    1. Front Matter
      Pages 157-157
    2. Haralambos Gavras, Irene Gavras, Hans R. Brunner
      Pages 159-164
    3. Victor J. Dzau, Leland G. Siwek, A. Clifford Barger
      Pages 165-168
    4. E. Darracott Vaughan Jr., Thomas A. Sos, Kenneth W. Sniderman, Thomas G. Pickering, David B. Case, Jean E. Sealey et al.
      Pages 173-180
  9. The Renin-Angiotensin-Aldosterone System for Blood Pressure Regulation and for Subdividing Patients to Reveal and Analyze Different Forms of Hypertension

    1. Front Matter
      Pages 181-181
    2. J. J. Brown, A. F. Lever, R. Fraser, J. I. S. Robertson, P. A. Mason, D. G. Beevers et al.
      Pages 195-198
    3. Thomas A. Wilson, Robert M. Carey
      Pages 199-203
    4. David H. P. Streeten, Gunnar H. Anderson Jr., Frederick S. Sunderlin Jr., Joseph S. Mallov, Jay Springer
      Pages 204-207
    5. G. A. MacGregor, N. D. Markandu, J. E. Roulston
      Pages 208-216
  10. The Control of Renin Release

    1. Front Matter
      Pages 217-217
    2. A. Zanchetti, A. Stella, G. Leonetti, G. Mancia
      Pages 219-227
    3. Alexander G. Logan, Alice Chatzilias
      Pages 228-231

About these proceedings


reached full definition in the 1940s by Kempner diet. The important role of adrenal aldosterone and associates in demonstrating the beneficial ef­ secretion in supporting human hypertension is now fects of a low salt rice diet for treating hypertensive well recognized as are the beneficial effects of patients. It became apparent that the value of rice blockade, especially in low-renin patients who ex­ was wholly related to its sodium content. A rice hibit inappropriate or absolute excesses of aldoste­ diet, or any other stringent low sodium diet, rone secretion. Further definition of the more sub­ greatly improves or completely corrects the hyper­ tle participation of aldosterone and of the factors tension of about ~ or so of all patients with essen­ that control aldosterone secretion in hypertensive subjects are promising areas for further research. tial hypertension. However, what is often forgotten is that little or no benefit accrues to the remaining THE NERVOUS SYSTEM majority of patients. Parallel studies of animal models has demon­ Besides the endocrine and excretory functions of strated the amplifying effect of a high sodium diet the kidney and the influence of dietary sodium on blood pressure and vice versa. Strains of rats and of aldosterone secretion, there has been long­ were developed which are especially sensitive to standing agreement about the important role of the pressor effects of a high sodium diet. In a way, the nervous system in blood pressure control.


Angiotensin II Antihypertonikum Dilatation Hypertonie cardiovascular hypertension

Editors and affiliations

  • John H. Laragh
    • 1
  • Fritz R. Bühler
    • 2
  • Donald W. Seldin
    • 3
    • 4
  1. 1.Cardiovascular Center, Division of CardiologyThe New York Hospital—Cornell Medical CenterNew YorkUSA
  2. 2.Department of Medicine and Department of ResearchUniversity HospitalBaselSwitzerland
  3. 3.University of Texas Health Science Center at DallasDallasUSA
  4. 4.Parkland Memorial HospitalDallasUSA

Bibliographic information