Neural Membranes

  • Editors
  • Grace Y. Sun
  • Nicolas Bazan
  • Jang-Yen Wu
  • Guiseppe Porcellati
  • Albert Y. Sun

Part of the Experimental and Clinical Neuroscience book series (ECN)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Membrane Phospholipids

    1. Front Matter
      Pages 1-1
    2. Giuseppe Porcellati
      Pages 3-35
    3. Grace Y. Sun, Wilson Tang, M. Dorota Majewska, David W. Hallett, Laurie Foudin, Steven Huang
      Pages 67-95
    4. Nicolas G. Bazan, Susana G. Morelli de Liberti, Elena B. Rodriguez de Turco, Maria F. Pediconi
      Pages 123-140
    5. Pak Hoo Chan, Robert A. Fishman, Susan Longar, Sylvia Chen, Susan Chew
      Pages 141-152
    6. Yasuo Masuzawa, Yoshiaki Onuma, Keizo Waku, Yoshio Ishima
      Pages 153-170
    7. Charles E. Pendley II, Lloyd A. Horrocks, Ronald F. Mervis
      Pages 171-190
  3. Receptors

  4. Membrane Structure and Functions

  5. Gangliosides

    1. Front Matter
      Pages 457-457
    2. Robert W. Ledeen, Mary C. Byrne, Fred J. Roisen Glee Yorke, Joseph R. Sclafani
      Pages 459-477
    3. G. Toffano, D. Benvegnuù, R. Dal Toso, L. Facci, A. Leon
      Pages 479-496
    4. R. K. Yu, H. Ebato, T. N. Seyfried
      Pages 497-511
    5. Yu-Teh Li, Su-Chen Li
      Pages 527-538
  6. Abstracts

  7. Back Matter
    Pages 579-584

About this book


One of the most active and productive areas of biological science in the past decade has been the study of the biochemical and biophysical prop­ erties of cell membranes. There is little doubt that membranes are essen­ tial components of all cellular systems and that each type of membrane manifests specific and characteristic cellular functions. In the nervous system, important events such as neurotransmission, receptor binding, ion transport, axonal transport, and cell uptake are all known to take place within the neural cell membrane. Phospholipids, one of the major components of membranes, not only provide the membrane with its structural integrity and physical proper­ ties, but also play an important role in regulating membrane function. Attention has recently been focused on the asymmetric localization of these molecules, the identification of discrete metabolic pools of phospholipids within the membrane matrix, and their involvement in sig­ nal transmission. Although synaptic membranes generally lack an active mechanism for the de novo biosynthesis of phospholipids, a number of enzymic routes are present for their interconversions and for facilitating metabolic turnover. Metabolites generated during the interconversion reactions may also exert a great influence in modulating membrane func­ tions. The phosphogylcerides of neural membranes are especially enriched in polyunsaturated fatty acids. However, only very small amounts of these fatty acids are present in the free form, and they are maintained in dynamic equilibrium with the membrane phospholipids.


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Bibliographic information