Advertisement

Gene Regulation by Steroid Hormones II

  • Arun K. Roy
  • James H. Clark
Conference proceedings

Table of contents

  1. Front Matter
    Pages I-XIII
  2. Bert W. O’Malley, Anthony R. Means, Joseph P. Stein
    Pages 1-16
  3. John N. Anderson, Jeff N. Vanderbilt, Kerry S. Bloom, Bonnie J. Germain
    Pages 17-59
  4. David J. Shapiro, Martin L. Brock, Marshall A. Hayward
    Pages 61-78
  5. B. Dworniczak, S. Kobus, K. Schaltmann-Eiteljor̈ge, O. Pongs
    Pages 79-91
  6. John D. O’Connor, Bryn Stevens
    Pages 93-99
  7. Nancy C. Lan, Thai Nguyen, Guy Cathala, Steven K. Nordeen, Manfred E. Wolff, Peter A. Kollman et al.
    Pages 119-133
  8. Gerald Litwack, Michael Mayer, Virginia Ohl, Bernard Sekula
    Pages 135-149
  9. Jan Carlstedt-Duke, Örjan Wrange, Sam Okret, John Stevens, Yee-Wan Stevens, Jan-Åke Gustafsson
    Pages 151-180
  10. Phillip P. Minghetti, Nancy L. Weigel, William T. Schrader, Bert W. O’Malley
    Pages 181-190
  11. Geoffrey L. Greene
    Pages 191-200
  12. Ernest J. Peck Jr., Katrina L. Kelner
    Pages 201-217
  13. Evelyn R. Barrack, Donald S. Coffey
    Pages 239-266
  14. Sheila M. Judge, Alan G. Saltzman, Shutsung Liao
    Pages 267-275
  15. Olli A. Jänne, Veli V. Isomaa, Antti E. I. Pajunen, William W. Wright, C. Wayne Bardin
    Pages 277-298
  16. Arun K. Roy, B. Chatterjee, N. M. Motwani, W. F. Demyan, T. S. Nath
    Pages 299-310
  17. G. H. Rasmusson, T. Liang, J. R. Brooks
    Pages 311-334
  18. A. K. Roy
    Pages 335-341
  19. Back Matter
    Pages 343-353

About these proceedings

Introduction

Receptors and Gene Expression It is now more than three years since the last Meadow Brook Conference on Hormones, and a great deal has happened in the meantime. We have become comfortable with the totally unanticipated fact that the coding sequences of genes are in discontinuous arrangements and that the RNA transcribed from them must be extensively processed to form messenger RNA. We have also learned about the strategy of "mixing and matching" of genetic segments so that a small amount of DNA can go a long way in producing a huge variety of different proteins, as in the immunoglobulin system. The explosive effort directed toward DNA sequence analysis has led us to the conclusion that there are signals within the DNA that specify sites of transcription initiation and possibly sites for interacting with regulatory molecules such as hor­ mones and their receptors. The current intense interest in the structure of chromatin beyond the nucleosome-that is, the superstructural characteris­ tics of the genetic material-is finally yielding meaningful results that give promise for understanding the regulation of gene activity. ROBERT F. GOLDBERGER Preface Research on the molecular mechanism of steroid hormone action continues at an extraordinary pace and a great deal of progress has been made. Steroid hormones have been localized on target genes providing the long awaited evidence for the concept of a direct effect of the steroid-receptor complex on gene regulation. Purified steroid receptors have been dissected to identify different functional domains.

Keywords

DNA Endoplasmatisches Reticulum Hormones RNA Steroid gene expression proteins regulation transcription

Editors and affiliations

  • Arun K. Roy
    • 1
  • James H. Clark
    • 2
  1. 1.Oakland UniversityRochesterUSA
  2. 2.Baylor College of MedicineHoustonUSA

Bibliographic information