Concepts in Viral Pathogenesis

1. Host Range and Tissue Tropism

   1. Enveloped Virus Maturation at Restricted Membrane Domains

      • Richard W. Compans

      Pages 123-129

   2. Viruses and Differentiation: The Molecular Basis of Viral Tissue Tropisms

      • Arnold J. Levine

      Pages 130-134

2. Virus Maturation and Diversity

   1. Front Matter

      Pages 135-135

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   2. Continuum of Change in RNA Virus Genomes

      • John J. Holland

      Pages 137-143

   3. Reassortment Continuum

      • Peter Palese

      Pages 144-151

   4. Immune Selection of Virus Variants

      • Janice E. Clements, Opendra Narayan

      Pages 152-157

   5. Antigenic Variants of Viruses and Their Relevance to Clinical Disease

      • Bellur S. Prabhakar, Abner Louis Notkins

      Pages 158-162

3. Virus Persistence

   1. Front Matter

      Pages 163-163

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   2. Unique Interactions of Retroviruses with Eukaryotic Cells

      • S. R. Tronick, S. A. Aaronson

      Pages 165-171

   3. Molecular Biology of Herpes Simplex Virus Latency

      • Edouard M. Cantin, Alvaro Puga, Abner Louis Notkins

      Pages 172-177

   4. Cellular Oncogenes and the Pathogenesis of Cancer

      • Robert A. Weinberg

      Pages 178-186

   5. Antibody Initiates Virus Persistence: Immune Modulation and Measles Virus Infection

      • Robert S. Fujinami, Michael B. A. Oldstone

      Pages 187-193

   6. Ovarian Infection and Transovarial Transmission of Viruses in Insects

      • Leon Rosen

      Pages 194-198

4. Virus-Interaction with the Immune System

   1. Front Matter

      Pages 199-199

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   2. Virus-Induced Immune Complex Formation and Disease: Definition, Regulation, Importance

      • Michael B. A. Oldstone

      Pages 201-209

   3. Virus-Induced Autoimmunity

      • Abner Louis Notkins, Takashi Onodera, Bellur Prabhakar

      Pages 210-215

   4. The Role of Immunospecific Receptors in Retrovirus-Induced Lymphomagenesis

      • M. S. McGrath, I. L. Weissman

      Pages 216-224

   5. Viruses as Regulators of Delayed Hypersensitivity T-Cell and Suppressor T-Cell Function

      • A. A. Nash

      Pages 225-230

   6. Mechanisms and Biological Implications of Virus-Induced Polyclonal B-Cell Activation

      • Rafi Ahmed, Michael B. A. Oldstone

      Pages 231-238

5. Evolving Concepts in Viral Pathogenesis Illustrated by Selected Animal Models

   1. Front Matter

      Pages 239-239

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The current proliferation of scientific information makes it difficult for even the most diligent reader to keep up with the latest developments in his/her own field, let alone other areas of interest. Review articles are one solution, but they too have become so voluminous and detailed that they often defeat the purpose for which they were intended. We have attempted to ease this problem by using a different format. In this volume on Concepts in Viral Pathogenesis, we have assembled a series of mini-reviews/editorials, 1,000 to 2,000 words in length. Each is a pithy distil­ lation of the state-of-the-art with emphasis on current thinking and unifying concepts rather than a compendium of the literature. The 53 articles, all written by active workers in their respective fields, are organized systemati­ cally so that the book will provide busy investigators, teachers and students of up-to-date information in a very brief and easily read­ a conceptual core able form. In addition, the authors have attempted to identify unresolved problems and point to future directions.

• Antigen
• Hepatitis
• Immune System
• Interferon
• Monoclonal Antibodies
• Regulation
• Virus
• Viruses
• antiviral drug
• autoimmunity
• infection
• infections
• inflammatory response
• influence
• viral infection
• infectious diseases

• National Institutes of Health, Bethesda, USA

  Abner Louis Notkins

• Department of Immunopathology, Scripps Clinic and Research Foundation, La Jolla, USA

  Michael B. A. Oldstone

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