Biological Methylation and Drug Design

Experimental and Clinical Role of S-Adenosylmethionine

  • Ronald T. Borchardt
  • Cyrus R. Creveling
  • Per Magne Ueland

Part of the Experimental Biology and Medicine book series (EBAM, volume 12)

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Protein and Phospholipid Methylations

    1. Front Matter
      Pages 1-1
    2. Woon Ki Paik, Sangduk Kim, Hyang Woo Lee
      Pages 15-23
    3. Melvin L. Billingsley, Randall L. Kincaid, Marina E. Wolf, Robert H. Roth, Walter Lovenberg, Carey D. Balaban et al.
      Pages 25-41
    4. Gerald L. Hazelbauer, John Bollinger, Chankyu Park, Dawn Nowlin, Maqsudul Alam
      Pages 43-53
    5. Jon Bremer, Kaare Norum, Pål Bjørnstad
      Pages 55-66
    6. Fusao Hirata, Masakazu Hatanaka, Yuji Wano, Keiichi Matsuda
      Pages 67-74
    7. I. Varela, M. Pajares, I. Merida, M. Villalba, C. Cabrero, P. Ortiz et al.
      Pages 89-99
    8. M. Lakher, R. J. Wurtman, J. Blusztajn, P. Holbrook, J-C. Maire, C. Mauron et al.
      Pages 101-110
  3. Nucleic Acid Methylations

    1. Front Matter
      Pages 111-111
    2. Thomas W. Sneider
      Pages 113-126
    3. Walter Doerfler, Klaus-Dieter Langner, Dagmar Knebel, Ulrike Weyer
      Pages 139-150
    4. Lionel A. Poirier, Mary J. Wilson, Narayan Shivapurkar
      Pages 151-161
    5. F. Rottman, P. Narayan, R. Goodwin, S. Camper, Y. Yao, S. Horowitz et al.
      Pages 189-200
  4. Regulation of S-Adenosylmethionine, S-Adenosylhomocysteine, and Methylthioadenosine Metabolism

    1. Front Matter
      Pages 201-201
    2. Nicholas M. Kredich, Malak Kotb, Deborah Campano German, Craig A. Bloch
      Pages 203-214
    3. Robert M. Hoffman, Peter H. Stern
      Pages 215-225
    4. Peter K. Chiang, George A. Miura
      Pages 239-251
    5. Michael S. Hershfield, V. Nambi Aiyar, Sara Chaffee, Sylvia Curtis, Michael L. Greenberg
      Pages 253-262
    6. P. M. Ueland, A. Svardal, H. Refsum., J. R. Lillehaug, J-S. Schanche, S. Helland
      Pages 263-274
    7. Dennis A. Carson, E. Olavi Kajander, Carlos J. Carrera, Hisashi Yamanaka, Taizo Iizasa, Masaru Kubota et al.
      Pages 275-286
  5. Clinical Aspects of S-Adenosylmethionine

    1. Front Matter
      Pages 313-313
    2. T. Bottiglieri, M. W. P. Carney, J. Edeh, M. Laundy, R. Martin, E. H. Reynolds et al.
      Pages 327-338
    3. Michael A. Sherer, Matthew V. Rudorfer, Giulio L. Cantoni, Robert N. Golden, William Z. Potter
      Pages 339-350
    4. J. R. Smythies, R. D. Alarcon, A. J. Bancroft, J. A. Monti, D. A. Morere, L. C. Tolbert et al.
      Pages 351-362
    5. I. Caruso, F. Montrone, M. Fumagalli, P. Sarzi, L. Boccassini, S. Santandrea et al.
      Pages 363-370
  6. Design, Synthesis, and Biological Evaluation of Transmethylation and Inhibitors

    1. Front Matter
      Pages 371-371
    2. Janice R. Sufrin, J. B. Lombardini, Debora L. Kramer, Vitauts Alks, Ralph J. Bernacki, Carl W. Porter
      Pages 373-384
    3. A. Holý, I. Votruba, A. Merta, E. DeClercq, R. Jelínek, K. Sláma et al.
      Pages 397-408
    4. John A. Montgomery, John A. Secrist III
      Pages 409-416
    5. Thomas P. Zimmerman, Gerald Wolberg, Carolyn R. Stopford, Karen L. Prus, Marie A. Iannone
      Pages 417-426
    6. James K. Coward
      Pages 427-434
    7. P. Blanchard, N. Dodic, J. L. Fourrey, M. Gèze, F. Lawrence, H. Malina et al.
      Pages 435-446
  7. Back Matter
    Pages 447-457

About this book


This book has been developed from its earlier and far less formal presentment as the proceedings of a symposium entitled The Biochemistry of S-Adenosylmethionine as a Basis for Drug Design that was held at the Solstrand Fjord Hotel in Bergen, Norway on June 30-July 4, 1985. The purpose of the symposium was to bring together scientists from various disciplines (biochemistry, pharmacology, virology, immunology, chemistry, medicine, and so on) to discuss the recent advances that have been made in our understanding of the biological roles of S­ adenosylmethionine (AdoMet) and to discuss the feasibility of utilizing AdoMet-dependent enzymes as targets for drug design. Thus the information provided herein will be of value not only to basic scientists involved in elucidating the role of AdoMet in biology, but also to medicinal chemists who are using this basic knowledge in the process of drug design. The volume should also be of interest to pharmacologists and clinicians involved in biological evaluation of potential therapeutic agents arising from the efforts of the biochemists and medicinal chemists. Each plenary speaker at the symposium was requested to submit a chapter reviewing recent contributions of their discipline to our base of knowledge about the biological role of AdoMet. Topics covered in this volume include protein and phospholipid methylations (Section A), nucleic acid methyl­ ations (Section B), the regulation of AdoMet, S-adenosylhomocysteine, and methylthioadenosine metabolism (Section C), clinical aspects of AdoMet (Section D), and the design, synthesis, and biological evaluation of trans­ methylation inhibitors (Section E).


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Editors and affiliations

  • Ronald T. Borchardt
    • 1
  • Cyrus R. Creveling
    • 2
  • Per Magne Ueland
    • 3
  1. 1.Pharmaceutical Chemistry DepartmentThe University of KansasLawrenceUSA
  2. 2.NIADDK, National Institutes of HealthBethesdaUSA
  3. 3.Department of PharmacologyUniversity of BergenBergenNorway

Bibliographic information