Analytical and Chromatographic Techniques in Radiopharmaceutical Chemistry

  • Donald M. Wieland
  • Michael C. Tobes
  • Thomas J. Manger

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Thin-Layer Chromatography

    1. Front Matter
      Pages 1-1
    2. Colin F. Poole, Hal T. Butler, Myra E. Coddens, Sheila A. Schuette
      Pages 3-37
  3. High Pressure Liquid Chromatography

    1. Front Matter
      Pages 101-101
    2. Adrian D. Nunn, Alan R. Fritzberg
      Pages 103-124
    3. Chester A. Mathis, Reese M. Jones, Joseph H. Chasko
      Pages 125-148
    4. Richard D. Hichwa
      Pages 171-179
  4. Applications

    1. Front Matter
      Pages 181-181
    2. Alan R. Fritzberg, Adrian D. Nunn
      Pages 183-212
    3. Jorge R. Barrio, Randy E. Keen, Diane C. Chugani, Gerald Bida, Nagichettiar Satyamurthy, Michael E. Phelps
      Pages 213-231
    4. Michael R. Kilbourn, Michael J. Welch, Carmen S. Dence, Keith R. Lechner
      Pages 251-260
    5. Donald J. Hnatowich
      Pages 279-293
  5. Back Matter
    Pages 295-300

About this book


In 1906, Michael T. Sweet first developed the chromatographic method by using an adsorbant to separate pigments. Since that time, the technological advances in TLC and HPLC have brought about new definitions of purity in parallel with the advances. Radiopharmaceutical chemistry is especially dependent on the chromat­ ographic technique because of the relatively small amount of material in most radiopharmaceuticals-often so small that the usual physical methods of analytical chemistry cannot be used. As a result, this collection of papers represents the key to successful radiopharmaceutical development by setting the standard for the pres­ of radiochemical purity. ent-day definition William C. Eckelman, Ph.D. Diagnostics Associate Director The Squibb Institute for Medical Research New Brunswick, New Jersey Preface The chapters herein are updated and expanded versions of presentations that the authors made at a symposium held on June 4, 1984 in Los Angeles, California under the sponsorship of the Radiopharmaceutical Science Council of the Society of Nuclear Medicine. All manuscripts were refereed. The intent of the symposium organizers was to enlist participants who work on a day-to-day basis with the analytical and chromatographic techniques to be discussed at the symposium. We feel confident that this distillation of hands-on experience will be of value to graduate students as well as experienced researchers in radio­ pharmaceutical chemistry and related fields which use radiotracer methodology.


chemistry diagnostics fluorescence nuclear medicine research

Editors and affiliations

  • Donald M. Wieland
    • 1
  • Michael C. Tobes
    • 1
  • Thomas J. Manger
    • 1
  1. 1.Division of Nuclear Medicine Department of Internal MedicineThe University of MichiganAnn ArborUSA

Bibliographic information