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Molecular Basis of Lymphokine Action

  • David R. Webb
  • Carl W. Pierce
  • Stanley Cohen

Part of the Experimental Biology and Medicine book series (EBAM, volume 18)

Table of contents

  1. Front Matter
    Pages i-xxviii
  2. Keynote Address

    1. Front Matter
      Pages 1-1
    2. George J. Todaro
      Pages 3-12
  3. Suppressor Factors

    1. Front Matter
      Pages N1-N1
    2. Masaru Taniguchi, Eiki Matsushita, Kenji Imai, Akihiko Koseki, Takayuki Sumida, Toshitada Takemori et al.
      Pages 13-20
    3. Judith A. Kapp, Craig M. Sorensen, Carl W. Pierce, David R. Webb
      Pages 33-46
    4. Robert R. Rich, Edward J. Fox, Medhat N. ElMasry
      Pages 59-71
  4. Interleukin 1

    1. Front Matter
      Pages 72-72
    2. Steven B. Mizel, Jill Suttles, Judith Giri, Jon Lewis, Patricia Kilian, Kathryn A. Paganelli
      Pages 73-81
    3. Emil R. Unanue, Casey T. Weaver, Robert C. Fuhlbrigge, Jeanne-Marie Kiely, David D. Chaplin
      Pages 97-104
    4. Steven K. Dower
      Pages 105-116
    5. Scott K. Durum, Alison Finnegan, Dan T. Brody, Elizabeth J. Kovacs, Mark R. Smith, Jay A. Berzofsky et al.
      Pages 117-122
  5. B Cell Growth and Differentiation Factors

    1. Front Matter
      Pages N2-N2
    2. Tadamitsu Kishimoto, Tetsuya Taga, Kiyoshi Yasukawa, Yasuo Watanabe, Tadashi Matsuda, Koichi Nakajima et al.
      Pages 123-136
    3. Julian L. Ambrus Jr., Anthony S. Fauci
      Pages 137-148
    4. Tim R. Mosmann, Holly Cherwinski, Daniel Cher, Robert L. Coffman
      Pages 149-159
  6. Interleukin 2

    1. Front Matter
      Pages 160-160
    2. Hiroshi Shibuya, Hisashi Harada, Mitsuo Maruyama, Takashi Fujita, Motoharu Seiki, Jun-Ichiro Inoue et al.
      Pages 161-169
    3. Warner C. Greene, Mitchell Dukovich, Yuji Wano, John H. Kehrl, Richard J. Robb
      Pages 171-179
    4. Verner Paetkau, Jennifer Shaw, John Elliott, Bill Pohajdak, Karen Meerovitch
      Pages 181-191
    5. John Hidden, Marzenna Wiranowska, Ronald Coffey, Steven Specter, Anne Galy, Jean-Louis Touraine et al.
      Pages 193-206
    6. Akira Yamaguchi, Toshimitsu Uede, Toshiya Murakami, Hisao Osawa, Tibor Diamantstein, Kokichi Kikuchi
      Pages 207-216
    7. Michael Sharon, Warren J. Leonard
      Pages 217-221
  7. Effector Factors

    1. Front Matter
      Pages 222-222
    2. Michael A. Palladino Jr.
      Pages 223-232
    3. R. Chris Bleackley, Corrinne G. Lobe, Calliopi Havele, Jennifer Shaw, Bill Pohajdak, Mark Redmond
      Pages 233-244
    4. J. W. Schrader, K. B. Leslie, I. Clark-Lewis, P. Pitha-Rowe, H. J. Ziltener, B. F. Fazekas
      Pages 245-260
    5. Kevin J. Tracey, Stephen F. Lowry, Anthony Cerami
      Pages 261-269
  8. Hematopoietic Growth Factors

    1. Front Matter
      Pages 282-282
    2. I. G. Young, H. D. Campbell, S. Ymer, T. Robins, D. R. Cohen, A. J. Hapel
      Pages 283-294
    3. P. Ralph, M. B. Ladner, A. M. Wang, E. S. Kawasaki, L. McConlogue, J. F. Weaver et al.
      Pages 295-311
    4. T. Yokota, H. Hagiwara, Y. Takebe, T. Otsuka, A. Miyajima, P. Meyerson et al.
      Pages 313-324
    5. I. Clark-Lewis, A. F. Lopez, M. Vadas, J. W. Schrader, L. Hood, S. B. H. Kent
      Pages 339-351
  9. Clincal Uses of Lymphokines

    1. Front Matter
      Pages 352-352
    2. William A. Peck, Leonard Rifas, Su-Li Cheng, Victor Shen, Roberto Pacifici, Louis V. Avioli
      Pages 353-358
    3. Marc Feldmann, Ravinder N. Maini, Marco Londei, Kathy Barrett, Martin Turner, Glenn Buchan
      Pages 359-369
    4. T. B. Strom, V. E. Kelley, J. R. Murphy, H. Osawa, N. L. Tilney, M. E. Shapiro et al.
      Pages 371-392
    5. Robert K. Oldham, John R. Yannelli, Gary B. Thurman, William W. West
      Pages 393-407
    6. B. M. Stadler, S. Brantschen, K. Hirai, K. Nakajima, A. Walz, A. L. de Wedk
      Pages 409-418
  10. Banquet Address

    1. Front Matter
      Pages N3-N3
  11. Workshop Summaries

    1. Front Matter
      Pages N4-N4
    2. Lawrence B. Lachman, Joost J. Oppenheim
      Pages 429-441
    3. William L. Farrar
      Pages 443-447

About this book

Introduction

The Fifth International Lymphokine Workshop was convened in Clearwater Beach, Florida, January 11-15, 1987. The theme chosen for the meeting was 'The Molecular Basis of Lymphokine Action," which reflected the opinion of the organizers as to how far the field had moved since the first Lymphokine Workshop only eleven years ago. As was evident at the last Lymphokine Workshop held in 1985, the contribution of molecular biology, particularly in the cloning of lymphokine genes, continues to play an important role in clarifying the structure of lymphokines, providing recombinant (read "pure") proteins for biological studies, and suggesting directions for studies of the molecular basis of lymphokine activity. The most recent lymphokines to yield to molecular cloning meth­ odology were the B-cell growth and differentiation factors, in partic­ ular BSF-1 or, as it is sometimes termed, interleukin 4. One of the surprises from this research is the broad spectrum of activities that can be attributed to this molecule, aside from its effects on B-cells, thus perhaps justifying its being called an interleukin. The interleukin 2 symposium demonstrated that even in a well-established research area, controversy and excitement can continue, when evidence was presented by several investigators indicating the presence of a second "converter" protein that changes the affinity of the now classical Tac antigen from a low to a high affinity IL-2 receptor.

Keywords

Activation Antigen Immunity Interleukin 1 Interleukin-2 Vivo cell division genes migration molecular biology proteins regulation

Editors and affiliations

  • David R. Webb
    • 1
  • Carl W. Pierce
    • 2
  • Stanley Cohen
    • 3
  1. 1.Roche Institute of Molecular BiologyNutleyUSA
  2. 2.Jewish HospitalWashington UniversitySt. LouisUSA
  3. 3.University of ConnecticutFarmingtonUSA

Bibliographic information