Biology of Copper Complexes

  • John R. J. Sorenson

Part of the Experimental Biology and Medicine book series (EBAM, volume 16)

Table of contents

  1. Front Matter
    Pages i-xix
  2. Physiologic Aspects of Copper Complexes

  3. Biochemical Aspects of Copper Complexes

    1. Front Matter
      Pages 57-57
    2. Frederick T. Greenaway, Coleen Young O’Gara
      Pages 67-79
    3. Thomas R. Gibson, Christopher C. Glembotski
      Pages 95-107
    4. Back Matter
      Pages 108-111
  4. Copper Complexes in Essential Metalloelement Nutriture and Disease States

    1. Front Matter
      Pages 113-113
    2. Carl L. Keen, Michael S. Clegg, Fay Ferrell, Glenn C. Hunter, Michael A. Dubick
      Pages 141-153
    3. Alfred W. Anderson
      Pages 155-163
    4. J. L. Johnson, N. R. Schneider, A. R. Doster, M. P. Carlson, H. W. Leipold
      Pages 165-174
    5. Darryl M. Williams, John R. Clement, F. Scott Kennedy, Harold Chen
      Pages 175-184
  5. Biological Aspects of Copper and Iron in Inflammation

    1. Front Matter
      Pages 185-185
    2. Lucrecia A. Hernandez, Matthew B. Grisham, D. Neil Granger
      Pages 201-214
    3. G. R. Elliott, M. J. P. Adolfs, M. van Batenburg, I. L. Bonta
      Pages 229-239
  6. Antiinflammatory Activities of Copper Complexes

  7. Analgesic and Antimicrobial Activities of Copper Complexes

    1. Front Matter
      Pages 299-299
    2. Shigeru Okuyama, Sanae Hashimoto, Hironaka Aihara, William M. Willingham, John R. J. Sorenson
      Pages 301-313
    3. Sam J. Bhathena, Lillian Recant
      Pages 315-328
    4. H. van der Goot, H. Smit, H.-D. Gaisser, H. Timmerman
      Pages 329-342
    5. Back Matter
      Pages 351-358
  8. Anticancer Activities of Copper Complexes and Iron Chelators

  9. Anticarcinogenic and Radioprotectant Activities of Copper Copplexes

    1. Front Matter
      Pages 411-411
    2. P. A. Egner, B. G. Taffe, T. W. Kensler
      Pages 413-424
    3. Hamid Salari, Max L. Baker, John B. Barnett, Lee S. F. Soderberg, William M. Willingham, John R. J. Sorenson
      Pages 437-449
    4. L. S. F. Soderberg, J. B. Barnett, M. L. Baker, H. Salari, J. R. J. Sorenson
      Pages 455-464
    5. Back Matter
      Pages 450-453
  10. Other Biological Effects of Complexes and Complexing Agents

    1. Front Matter
      Pages 465-465
  11. Poster Presentations

    1. Front Matter
      Pages 491-491

About this book


In 1928, it was discovered that copper was essential for normal human metabolism. Ten years later, 1938, it was observed that patients with rheumatoid arthritis had a higher than normal serum copper concentration, which returned to normal wi th remission of this disease. Thirteen years later, it was found that copper complexes were effective in treating arthritic diseaseS. The first report that copper complexes had antiinflammatory activity in an animal model of in­ flammation appeared twenty-two years after the discovery of essen­ tiality. In 1976, it was suggested that the active forms of the anti­ arthritic drugs are their copper complexes formed in vivo. This suggestion was confirmed and extended in the interim with over 1000 recent publications, and many of these were addressed in the proceed­ ings of our first symposium, published in 1982. The present symposium was organized to present new normal physiological, nutritional, and biochemical aspects of essential metal­ loelement metabolism as well as variations in metabolism associated with disease states. In addition new data concerning antimicrobial, antiinflammatory, antiulcer, anticancer, anticarcinogenic, analgesic, and radioprotectant activities of copper complexes were presented. These activities are consistent with the notion that they represent the facilitation of normal copper-dependent metabolic processes in dis­ ease states. The presentations and interactive discussions that fol­ lowed are contained in these proceedings. John R. J. Sorenson Dedication These proceedings are dedicated to those who made this truly memorable scientific and social Arkansas experience possible.


Arthritis Lipid biology enzymes inflammation metabolism receptor rheumatic diseases rheumatoid arthritis synthesis

Editors and affiliations

  • John R. J. Sorenson
    • 1
  1. 1.University of Arkansas for Medical SciencesLittle RockUSA

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