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The Serotonin Receptors

  • Elaine Sanders-Bush

Part of the The Receptors book series (REC)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Historical Perspectives

    1. Front Matter
      Pages 1-1
    2. Samuel S. Wang, Stephen J. Peroutka
      Pages 3-20
  3. Characterization of Serotonin Receptor Binding Sites

    1. Front Matter
      Pages 21-21
    2. Robert A. Lyon, Milt Titeler
      Pages 59-88
    3. J. M. Palacios, M. M. Dietl
      Pages 89-138
  4. Biochemical Mechanisms of Receptor Action

    1. Front Matter
      Pages 139-139
    2. Michael De Vivo, Saul Maayani
      Pages 141-179
    3. Elaine Sanders-Bush
      Pages 181-198
  5. Correlation of Binding Sites with Function

    1. Front Matter
      Pages 199-199
    2. Derek N. Middlemiss
      Pages 201-224
    3. G. K. Aghajanian, J. S. Sprouse, K. Rasmussen
      Pages 225-252
    4. Richard A. Glennon, Irwin Lucki
      Pages 253-293
    5. Marlene L. Cohen
      Pages 295-316
  6. Regulation of Serotonin Receptors

    1. Front Matter
      Pages 317-317
    2. Alan Frazer, Steve J. Offord, Irwin Lucki
      Pages 319-362
  7. Future Vistas

    1. Front Matter
      Pages 363-363
    2. Elaine Sanders-Bush
      Pages 365-366
  8. Back Matter
    Pages 367-388

About this book

Introduction

Serotonin (5-HT) was isolated and chemically characterized nearly four decades ago, and is now generally accepted to function as a neurotransmitter and neuromodulatory agent. Early research focused on the measurement of concentrations, synthesis, and metabolism of 5-HT, and only recently has the focus shifted to characterization of 5-HT receptors. Gaddum and Picarelli first sug­ gested in 1957 that the effect of 5-HT in the guinea pig ileum is mediated by two pharmacologically distinguishable receptors; however, the possibility of dual5-HT receptors was not explored systematically or successfully until the past decade. It is now clear that more, perhaps many more, subclasses of 5-HT receptors exist. The purpose of this book is to provide an up-to-date report on 5-HT receptors. This is a difficult task considering the astonishing speed at which research in this field is expanding. As the first of what we can expect to be a steady stream of monographs focusing on 5-HT receptors, the book confirms that we are in an exciting time in the history of 5-HT. For those of us who have been work­ ing on 5-HT for many years, our dream of equal progress and recognition with the more extensively studied catecholamines is finally being realized. We now have a Serotonin Club that held its first international scientific meeting in 1987, and several more international meetings are in the planning stages.

Keywords

Nervous System Vivo biochemistry catecholamines cognition cortex metabolism neurotransmitter pharmacology physiology platelets protein receptor signal transduction tissue

Editors and affiliations

  • Elaine Sanders-Bush
    • 1
  1. 1.Department of Pharmacology and PsychiatryVanderbilt University School of MedicineNashvilleUSA

Bibliographic information