Molecular Mechanisms of Alcohol

Neurobiology and Metabolism

  • Grace Y. Sun
  • P. Kevin Rudeen
  • W. Gibson Wood
  • Yau-Huei Wei
  • Albert Y. Sun

Part of the Experimental Biology and Medicine book series (EBAM, volume 21)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Ethanol Action on Neurochemical Mechanisms

    1. Front Matter
      Pages 1-1
    2. W. G. Wood, C. Gorka, A. M. Rao, F. Schroeder
      Pages 3-13
    3. Grace Y. Sun, Renuka Chandrasekhar, Hsueh-Meei Huang
      Pages 15-38
    4. Fulton T. Crews, Norbert J. Pontzer, L. Judson Chandler
      Pages 39-55
    5. Teng-nan Lin, Grace Y. Sun
      Pages 107-118
    6. Paula L. Hoffman, Hideaki Ishizawa, Gyula Szabó, J. R. Dave, Li-Ing Liu, Boris Tabakoff
      Pages 119-131
    7. David T. Wong, James M. Murphy
      Pages 133-146
    8. P. Kevin Rudeen, Julia A. Creighton
      Pages 147-165
  3. Ethanol and Cell Culture

    1. Front Matter
      Pages 167-167
    2. Sujata Tewari, Thanh Hoang, David Winn, Kimberly Boyd, Hemalatha Parekh
      Pages 169-192
    3. Christer Alling, Elisabeth Hansson, Per Simonsson
      Pages 193-205
  4. Ethanol Effects on Metabolism

    1. Front Matter
      Pages 225-225
    2. Chiao-Chicy Chen, Eng-Kung Yeh
      Pages 249-255
    3. F. F. Ahmad, D. L. Cowan, A. Y. Sun
      Pages 257-277
    4. M. R. Lakshman, Stuart J. Chirtel, Laura L. Chambers
      Pages 305-316
    5. Kenneth E. McMartin, William R. Bates, Tamaca Fortney, Sneh D. Bhandari
      Pages 327-334
    6. Eng-Kung Yeh, Hai-Gwo Hwu, Chiao-Chicy Chen, Yuan-Li Yeh
      Pages 335-355
  5. Animal Models for Alcohol Research

    1. Front Matter
      Pages 357-357
    2. Lawrence Lumeng, Ting-Kai Li, William J. McBride, James M. Murphy, Sandra L. Morzorati, Janice C. Froehlich
      Pages 359-370
    3. Albert Y. Sun, M. E. Tumbleson, James O. Dexter, Grace Y. Sun
      Pages 371-388
  6. Back Matter
    Pages 389-397

About this book


Alcohol abuse throughout the world is associated with serious social and medical implications. Problems such as intoxication, tol­ erance, and development of physical dependence have been well recognized. The central nervous system and the liver are especially affected. There is little doubt that alcohol abuse can result in organ damage, which in turn leads to deleterious health consequences to the individual. Understanding ethanol action presents a special and functional diver­ challenge because of its molecular simplicity sity. In fact, the ability for alcohol to disrupt cellular function is at­ tributed to its cellular injury without regard to an apparent specific mechanism of action. Nevertheless, the key to an effective treatment to this problem is through research into understanding the mechan­ isms underlying how ethanol interacts with cells and membranes. This book is the result of a cooperative effort among scientists from many nations who met in a symposium in Taipei, Taiwan, ROC, July 1988. The focus of this book is on experimental ap­ proaches to better understand the molecular mechanisms of ethanol on the biological system. These recent advances in the examination of the alcohol effects on cellular function are divided into four sec­ tions. The first section addresses specific actions of ethanol on the central nervous system. The second section is directed to the use of cell cuI tures in ethanol research and the usefulness of cell cultures in examination of the effects of ethanol in vitro.


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Editors and affiliations

  • Grace Y. Sun
    • 1
  • P. Kevin Rudeen
    • 2
  • W. Gibson Wood
    • 3
  • Yau-Huei Wei
    • 4
  • Albert Y. Sun
    • 1
  1. 1.Sinclair Research FarmUniversity of MissouriColumbiaUSA
  2. 2.Department of Anatomy and NeurobiologyUniversity of MissouriColumbiaUSA
  3. 3.VA Medical Center and Department of PharmacologyUniversity of Minnesota School of MedicineMinneapolisUSA
  4. 4.Department of BiochemistryNational Yang-Ming Medical CollegeTaipeiTaiwan, ROC

Bibliographic information