Epstein-Barr Virus and Human Disease • 1988

  • Dharam V. Ablashi
  • Alberto Faggioni
  • Gerhard R. F. Krueger
  • Joseph S. Pagano
  • Gary R. Pearson

Part of the Experimental Biology and Medicine book series (EBAM, volume 20)

Table of contents

  1. Front Matter
    Pages i-xxvii
  2. Cellular and Molecular Biology of EBV

    1. Front Matter
      Pages 1-1
    2. David Liebowitz, Elliott Kieff, Jeffery Sample, Mark Birkenbach, Fred Wang
      Pages 3-15
    3. G. Miller, N. Talyor, J. Countryman, C. Rooney, D. Katz, J. Kolman et al.
      Pages 17-35
    4. R. F. Ambinder, W. A. Shah, E. D. Fixman, B. C. Lambe, D. R. Rawlins, G. S. Hayward et al.
      Pages 37-42
    5. Anna Chevallier Greco, H. Gruffat, E. Manet, Alain Sergeant
      Pages 43-47
    6. Shannon Kenney, James Kamine, Elizabeth Holley-Guthrie, Jung-Chung Lin
      Pages 55-60
    7. M. J. Allday, D. Kundu, B. E. Griffin
      Pages 61-62
    8. Ulrike Leser, Fritz Schwarzmann, Manfred Marschall, Hans Wolf
      Pages 63-67
    9. Mei-Ru Chen, Tswey-Ying Hsu, Jen-Yang Chen, Czau-Siung Yang
      Pages 69-74
    10. Y.-S. Chang, S.-Y. Lin, P.-F. Lee, H.-C. Chung, M.-S. Tsai
      Pages 79-82
  3. Molecular Pathobiology of EBV Infections

    1. Front Matter
      Pages 83-83
    2. Nancy Raab-Traub, Kevin Gilligan, Hiroshi Sato, Kathryn Flynn, Sharon Neese Edmiston, Jian-Jing Chen
      Pages 85-97
    3. Hans Wolf, Wolfgang Jilg, Christine Markert, Susanne Modrow, Christian Zietz, Eberhard Wilmes
      Pages 99-103
    4. Jung-Chung Lin, Shannon Kenney, Joseph S. Pagano
      Pages 105-112
    5. L. T. Wen, A. Tanaka, M. Nonoyama
      Pages 113-118
    6. M. R. Torrisi, M. Cirone, A. Pavan, C. Zompetta, G. Barile, L. Frati et al.
      Pages 125-130
    7. John W. Sixbey, Pamela Shirley, Victor Israele
      Pages 131-135
    8. S. Finerty, L. S. Young, L. Brooks, F. T. Scullion, A. B. Rickinson, A. J. Morgan
      Pages 141-144
    9. Maria G. Masucci, Bertha Contreras, Kerstin Falk, Barbro Ehlin-Henriksson, Janos Minarovits, George Klein et al.
      Pages 145-148
    10. G. Decaussin, S. Finerty, C. X. Zhang, A. Morgan, T. Ooka
      Pages 149-153
    11. J. S. Rhim, R. I. Fox, D. V. Ablashi, S. Z. Salahuddin, A. Buchbinder, S. F. Josephs
      Pages 155-161
    12. Kathleen L. Tarr, Hai-Ying Zhang, Ronald Glaser
      Pages 163-167
  4. Immunological Aspects of EBV Infections

    1. Front Matter
      Pages 169-169
    2. A. B. Rickinson
      Pages 171-178
    3. José Menezes, Jean Gosselin, Smriti Kundu
      Pages 179-187
    4. B. A. Blazar, P. Sereno, L. Stevenson, A. M. Murphy
      Pages 189-193
    5. Maria Teresa Bejarano, Maria Grazia Masucci, George Klein, Eva Klein
      Pages 195-200
    6. D. J. Moss, I. S. Misko, S. R. Burrows, K. Burman, R. McCarthy, T. B. Sculley
      Pages 201-206
    7. Jørgen Petersen, Gary Rhodes, Jean Roudier, Dennis A. Carson, John H. Vaughan
      Pages 207-212
    8. L. Ferradini, S. Miescher, C. Barras, P. Busson, M. Lipinski, V. von Fliedner et al.
      Pages 213-218
    9. Wolfgang Jilg, Helga Mairhofer, Christine Markert, Hans Wolf
      Pages 219-222
    10. G. Ragona, A. Tabilio, A. Fruscalzo, L. Annino, A. Angeloni, L. Bertolini
      Pages 231-235
  5. Clinical Syndromes Associated with EBV Infections

    1. Front Matter
      Pages 237-237
    2. Robert I. Fox, Ichiro Saito
      Pages 239-250
    3. J. Becker, U. Leser, M. Marschall, A. Langford, W. Jilg, P. Reichart et al.
      Pages 267-270
    4. D. P. Huang, K. M. Chan, S. Y. Tsao, Y. H. Ho, L. J. McGuire, H. K. Ng et al.
      Pages 277-280
    5. M. M. Hitt, T. Hara, M. J. Allday, L. Karran, M. D. Jones, B. E. Griffin
      Pages 281-286

About this book


Epstein-Barr virus (EBV) is one of the most widespread human viruses, with over 80% of the general population exposed by young adulthood, as determined by antibody studies. Initial infection usu­ ally occurs during childhood or the teenage years. It is clear that, de­ pending on the age of the recipient, clinical manifestations of the primary infection can vary. It has been known for 20 years that EBV is the etiologic agent of acute infectious mononucleosis (IM) and is also closely associated with African Burkitt's lymphoma (BL) and naso­ it is a pharyngeal carcinoma (NPC). There is increasing evidence that factor in the etiology of B-celllymphomas, which arise at a high fre­ quency in immunodeficient populations. EBV may also contribute to the development of autoimmune disease. Thus, this virus continues to attract world-wide attention. The major target cell for EBV infection has now been conclusively identified as the complement receptor-type 2 (CR2), the Cd/Cdg 3 3 receptor on B lymphocyte. It is apparent, however, that other cells also can become infected by EBV, such as epithelial cells in the parotid gland and other epithelial cells in the upper respiratory tract. This might help account for the EBV-assodated carcinomas of the upper respiratory tract. The first in a series of international symposia on EBV -associated diseases focused primarily on Burkitt's-type lymphomas or on NPC (Kyoto 1977; Dusseldorf 1980; Kuala Lumpur 1982) and emphasized mainly the clinical elements of these diseases. Subsequent symposia (Loutraki, 1984; St.


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Editors and affiliations

  • Dharam V. Ablashi
    • 1
  • Alberto Faggioni
    • 2
  • Gerhard R. F. Krueger
    • 3
  • Joseph S. Pagano
    • 4
  • Gary R. Pearson
    • 5
  1. 1.National Cancer InstituteBethesdaUSA
  2. 2.Universitá “La Sapienza,”RomaItaly
  3. 3.University of CologneCologneWest Germany
  4. 4.University of North CarolinaChapel HillUSA
  5. 5.Georgetown University Medical SchoolUSA

Bibliographic information