Handbook of the Hemopoietic Microenvironment

  • Mehdi Tavassoli

Part of the Contemporary Biomedicine book series (CB, volume 9)

Table of contents

  1. Front Matter
    Pages i-xxii
  2. John J. Trentin
    Pages 1-86
  3. Marshall A. Lichtman, Charles H. Packman, Louis S. Constine
    Pages 87-140
  4. Robert S. McCuskey
    Pages 141-155
  5. William H. Knospe
    Pages 189-218
  6. Peter J. Quesenberry
    Pages 253-285
  7. Joao L. Ascensao, Esmail D. Zanjani
    Pages 335-368
  8. Renate E. Gay, C. W. Prince, K. S. Zuckerman, S. Gay
    Pages 369-398
  9. Kenneth S. Zuckerman, Charles W. Prince, Steffen Gay
    Pages 399-432
  10. N. T. Shahidi, W. B. Ershler
    Pages 433-444
  11. Back Matter
    Pages 445-453

About this book


In 1868, Ernst Neumann recognized that blood cells re­ quire continuous replenishment during postnata1life. Before him, the assumption was that cells of the blood, like nerves once formed in the embryo, remain in the body throughout life. Neumann also recognized that this process occurred within the bone marrow, because this tissue provided a fa­ vorable environment for proliferation and differentiation of blood cell precursors. Vera Danchakoff, the Russian embryologist working in the US, in 1916 made an analogy to the soil and the seed. Bone marrow forms the soil, providing a favorable environment for the growth of seed, the hemopoietic stem cell, and other progenitor cells. Imagine in the remote past a heap of similar tree seeds. These seeds develop in our moderate climate into a tall and many branched tree. Suppose the wind bears a part of the seeds away and brings them to a land possessing different environmental conditions, we will say the arc­ tic lands. There the seeds may develop but they may pro­ duce trees no higher than our moss.


Macrophages Vivo glycoprotein protein proteins regulation

Editors and affiliations

  • Mehdi Tavassoli
    • 1
  1. 1.Veterans Administration Medical CenterUniversity of Mississippi School of MedicineJacksonUSA

Bibliographic information