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Tamoxifen

Beyond the Antiestrogen

  • John A. Kellen

Table of contents

  1. Front Matter
    Pages i-x
  2. J. A. Kellen
    Pages 1-23
  3. Charles Rowlatt
    Pages 25-41
  4. Myles C. Cabot, Armando E. Giuliano
    Pages 43-58
  5. Annie J. Sasco, Isabelle Gendre
    Pages 59-92
  6. Edward Baral, Eva Nagy, Istvan Berczi
    Pages 137-178
  7. Taisen Iguchi, Yasuhiko Ohta
    Pages 179-199
  8. Marc E. Bracke, Frans M. Van Roy, Vincent Castronovo, Marc M. Mareel
    Pages 267-284
  9. Liam J. Murphy, Leigh C. Murphy
    Pages 285-301
  10. Markku Ahotupa
    Pages 303-320
  11. Anni M. Wärri, Pirkko L. Härkönen
    Pages 343-358
  12. J. A. Kellen
    Pages 369-374
  13. Back Matter
    Pages 375-377

About this book

Introduction

Tamoxifen has persisted as a widely accepted and administered drug for almost 25 years. Following the many scientific papers and books on the subject, it has remained a very intriguing substance. This, perhaps, is the reason for another monograph on Tamoxifen. It is regrettably true that overviews, even when up to date after exhaustive research - the shibboleth of our cultures -, rapidly lose relevance with the passage of time. Scientists can sometimes be pictured as deep sea divers, who plunge into the unknown in search of a hitherto unknown world. Their descent is exciting, but eventually they must come up for air and integrate their experiences with others who also had to resurface. This book intends to collect and, where possible, to collate recent, but sometimes seemingly unrelated information. To quote Stephane Mallarme: "Everything in the world exists to end up in a book". Even if this is a tad cynical, it might not be far from the truth. If a little knowledge is a dangerous commodity, one can also add - tongue in cheek - that a vast amount of knowledge can be truly hazardous. It is likely that what might seem as entangled data is confusing, especially for those satisfied with the comfortable interpretation of Tamoxifen as an antiestrogen which has long been found insufficient. The complexity of its mechanisms and effects defies simple explanations and may even seem capricious, but only because of our ignorance.

Keywords

DNA Enigma Tamoxifen cancer drug drug resistance growth growth factor lipide metabolism protein research resistance signal transduction

Editors and affiliations

  • John A. Kellen
    • 1
  1. 1.TorontoCanada

Bibliographic information