Chemical Induction of Cancer

Modulation and Combination Effects an Inventory of the Many Factors which Influence Carcinogenesis

  • Joseph C. Arcos
  • Mary F. Argus
  • Yin-tak Woo

Table of contents

  1. Front Matter
    Pages i-xxxii
  2. Prefatory Chapter

  3. Cross-Reactions Between Carcinogens. Modification of Chemical Carcinogenesis by Noncarcinogenic Agents

    1. Front Matter
      Pages 21-21
    2. Gary J. Kelloff, Charles W. Boone, Vernon E. Steele, Judith R. Fay, Caroline C. Sigman
      Pages 73-122
    3. Promotion and Cocarcinogenesis

      1. Friedrich Marks, Michael Schwarz, Gerhard Fürstenberger
        Pages 123-124
      2. Friedrich Marks, Gerhard Fürstenberger
        Pages 125-160
      3. Michael Schwarz
        Pages 161-179
    4. Yin-tak Woo, Gregg Polansky, Joseph C. Arcos, Jeff Stokes DuBose, Mary F. Argus
      Pages 185-203
    5. James E. Trosko, Chia-Cheng Chang, Burra V. Madhukar, Emmanuel Dupont
      Pages 205-225
  4. Exogenous Factors and Endogenous Biological Parameters that Modulate Chemical Carcinogenesis

    1. Front Matter
      Pages 235-235
    2. Karen A. Sullivan, John E. Salvaggio
      Pages 237-272
    3. The Effect of Diet on Tumor Induction

      1. David Kritchevsky
        Pages 273-283
      2. Erwin J. Hawrylewicz
        Pages 284-315
      3. Edgar Petru, Yin-tak Woo, Martin R. Berger
        Pages 316-334
      4. Maryce M. Jacobs, Roman J. Pienta
        Pages 335-356
      5. David Kritchevsky
        Pages 357-366
      6. Joseph C. Arcos, Mary F. Argus, Yin-tak Woo
        Pages 370-371
    4. Yvonne Leutzinger, John P. Richie Jr.
      Pages 373-395
    5. The Effect of Hormones on Tumor Induction

      1. Joseph C. Arcos, Mary F. Argus, Yin-tak Woo
        Pages 397-398
      2. Joseph C. Arcos, Mary F. Argus, Yin-tak Woo
        Pages 399-418
      3. Joseph C. Arcos, Mary F. Argus, Yin-tak Woo
        Pages 419-430
      4. Joseph C. Arcos, Mary F. Argus, Yin-tak Woo
        Pages 431-445
      5. Joseph C. Arcos, Mary F. Argus, Yin-tak Woo
        Pages 445-449
    6. Norman R. Drinkwater
      Pages 451-472
    7. Mechanisms of Viral Tumorigenesis and the Combination Effects of Viruses and Chemical Carcinogens

      1. Joseph C. Arcos
        Pages 509-510
      2. Joseph C. Arcos, Lawrence R. Boone, William C. Phelps
        Pages 511-540
      3. Lawrence R. Boone, K. Gregory Moore, William C. Phelps, Yin-tak Woo
        Pages 541-609
      4. Joseph C. Arcos
        Pages 623-626
    8. Wolfgang H. Vogel
      Pages 627-640
    9. Joseph C. Arcos, Mary F. Argus, Yin-tak Woo
      Pages 640-643
    10. Bary W. Wilson, Jeffrey D. Saffer
      Pages 645-674
  5. Back Matter
    Pages 675-711

About this book


In the approach to the analysis of disease, including, of course, cancer, two major thrusts may be distinguished. These may be referred to, in shorthand, as agents and processes: the causative agents (chemical, microbial, physical, environmental, and psychosocial) and the organismic processes, initiated and furthered by the agents, culminating in observable pathology (at the macromolecular, cytological, histological, organ function, locomotor, and behavioral levels). The past 25 years, since the appearance of the first volume of the predecessor series (1) authored by the Editors of this present volume, have seen an impressive number of studies on chemicals (and other agents) as etiologic factors in the induction of cancer. The major emphasis has been on the discovery of many chemical carcinogens of widely different structures, their metabolism by various tissues and cells, and, in turn, their molecular-biochemical effects on the cells. This rapidly expanded body of information, as effectively covered in the predecessor volumes, is an excellent entree to the second half of the overall problem of chemical carcinogenesis, the processes. The active agents trigger a large array of molecular-biochemical alterations to which the target cells, target tissues, and target organisms respond in many select and common ways. This second major aspect of the induction of cancer by chemicals (and by other agents)- the sequence of cellular and tissue changes clearly relevant to cancer-remains the challenge for the future.


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Editors and affiliations

  • Joseph C. Arcos
    • 1
    • 2
  • Mary F. Argus
    • 1
    • 2
  • Yin-tak Woo
    • 1
  1. 1.U.S. Environmental Protection AgencyWashingtonUSA
  2. 2.Tulane University School of MedicineNew OrleansUSA

Bibliographic information