Thrombopoiesis and Thrombopoietins

Molecular, Cellular, Preclinical, and Clinical Biology

  • David J. Kuter
  • Pamela Hunt
  • William Sheridan
  • Dorothea Zucker-Franklin

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Carl W. Jackson, Julie T. Arnold, Tamara I. Pestina, Paula E. Stenberg
      Pages 3-39
    3. Dorothea Zucker-Franklin
      Pages 41-62
    4. Jack Levin
      Pages 63-78
  3. The Search for the Physiologic Regulator of Platelet Production

    1. Front Matter
      Pages 93-93
    2. Eric M. Mazur
      Pages 95-108
    3. Françoise Wendling, Sylvie Gisselbrecht
      Pages 109-122
    4. Françoise Wendling, Najet Debili, William Vainchenker
      Pages 123-134
    5. David J. Kuter, Hiroshi Miyazaki, Takashi Kato
      Pages 143-164
  4. Molecular Biology

    1. Front Matter
      Pages 179-179
    2. Austin L. Gurney, Frederic J. de Sauvage
      Pages 181-188
  5. Cellular Biology

    1. Front Matter
      Pages 215-215
    2. Najet Debili, Elisabeth Cramer, Françoise Wendling, William Vainchenker
      Pages 217-235
    3. Kenneth Kaushansky, Virginia C. Broudy, Jonathan G. Drachman
      Pages 257-270
    4. Laurence A. Harker, Ulla M. Marzec, Christopher F. Toombs
      Pages 285-297
  6. Preclinical Biology

    1. Front Matter
      Pages 299-299
    2. Laurence A. Harker, Christopher F. Toombs, Richard B. Stead
      Pages 301-319
    3. Ann M. Farese, Thomas J. MacVittie
      Pages 321-347
    4. Frederic J. de Sauvage, Mark W. Moore
      Pages 349-356
  7. Clinical Biology

    1. Front Matter
      Pages 357-357
    2. David J. Kuter
      Pages 377-395
  8. Back Matter
    Pages 397-412

About this book


David Kuter and a host of leading international researchers summarize in one volume all the knowledge of thrombopoietins (TPO) available today. The distinguished experts review the history of the search to discover TPO, describe the molecular and biological characteristics of this new molecule, and present the results of the preclinical animal experiments that will guide clinical use of this new hormone. Along the way they provide the most recent and comprehensive guide to the biology of megakaryocytes and platelets.


Regulation Vivo gene expression genes leukemia virus molecular biology platelets signal transduction transcription

Editors and affiliations

  • David J. Kuter
    • 1
  • Pamela Hunt
    • 2
  • William Sheridan
    • 2
    • 3
  • Dorothea Zucker-Franklin
    • 4
  1. 1.The MGH Cancer CenterMassachusetts General HospitalBostonUSA
  2. 2.Amgen Inc.Thousand OaksUSA
  3. 3.Division of Hematology-Oncology, Department of MedicineUCLA School of MedicineLos AngelesUSA
  4. 4.Department of MedicineNew York University Medical CenterNew YorkUSA

Bibliographic information