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Fetal Islet Transplantation

Implications for Diabetes

  • Charles M. Peterson
  • Lois Jovanovic-Peterson
  • Bent Formby
Book

Table of contents

  1. Front Matter
    Pages i-xxiv
  2. Charles M. Peterson, Lois Jovanovic-Peterson, Bent Formby, Lee Ducat
    Pages 1-7
  3. Stellan Sandler, Arne Andersson, Ingemar Swenne, Leif Jansson, Olle Korsgren, Annika Schnell Landström et al.
    Pages 9-42
  4. Bent Formby, Liberty Walker, Charles M. Peterson
    Pages 55-66
  5. Jeffrey E. Christiaansen, Charles M. Peterson
    Pages 67-77
  6. Siegfried Schmidt, Barbara Wilke, Beate Kuttler, Ingrid Klöting
    Pages 79-92
  7. Ben J. Walthall, Kathleen A. Elias, William L. Godfrey, Yvonne E. McHugh, Paul S. Moss, Robert A. Noonan et al.
    Pages 93-110
  8. Bernard E. Tuch
    Pages 127-164
  9. Lois Jovanovic-Peterson, Kristen Williams, Murray Brennan, Kurt Fuhrmann, William Rashbaum, Liberty Walker et al.
    Pages 185-195
  10. Back Matter
    Pages 197-205

About this book

Introduction

The breadth of research efforts represented by the many excellent papers in these proceedings is an eloquent testimonial to the idea of one man­ Dr. Josiah Brown-to whose memory this volume is dedicated. His tragic and unexpected loss in a swimming accident in August 1985 brought to an abrupt close a long and distinguished career as a physician and scientist. The possibility of using fetal pancreas tissue for transplantation into insulin-deficient diabetic recipients had intrigued Dr. Brown for several years prior to 1972, when he began in earnest to assemble a research team to explore this idea in detail. He felt that improvements in the formulation and administration of insulin (even the later recombinant human insulin) had taken us about as far as we could go in treating diabetes, and that methods for achieving complete cures must be explored. Numerous advantages of the fetal pancreas quickly became apparent, and were explored scientifically by Dr. Brown and his group. Transplanted pancreas tissue from a fetal donor of the appropriate developmental stage engrafts quickly, and can reverse diabetes very efficiently (1-3). By shunting the venous'drainage of the graft into the hepatic portal vein, a single pancreatic rudiment can, in time, provide enough insulin to restore normoglycemia and urine volume in a diabetic adult recipient (4). As with fetal pancreas rudiments in culture, transplanted fetal pancreas tissue loses its exocrine character, while continuing to develop and maintain endocrine function.

Keywords

Antigen Diabetes Diabetes mellitus Pancreas Pancreatic Islets insulin tissue transplantation

Editors and affiliations

  • Charles M. Peterson
    • 1
  • Lois Jovanovic-Peterson
    • 1
  • Bent Formby
    • 1
  1. 1.Sansum Medical Research FoundationSanta BarbaraUSA

Bibliographic information