Experimental Malignant Hyperthermia

  • Charles H. Williams

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Charles H. Williams, Susan E. Dozier, Charles W. Gehrke, Klaus O. Gerhardt, Joseph K. Wong
    Pages 7-19
  3. Klaus O. Gerhardt, Charles W. Gehrke, Charles H. Williams, Joseph K. Wong
    Pages 20-29
  4. Charles H. Williams, Susan E. Dozier, Mary Farias
    Pages 30-45
  5. R. R. Anderson, M. A. Akasha, D. A. Nixon, Charles H. Williams
    Pages 46-58
  6. Mariam A. Marvasti, Charles H. Williams
    Pages 59-77
  7. Wilfried K. Ilias, Charles H. Williams, Susan E. Dozier, Robert T. Fulfer
    Pages 78-89
  8. Charles E. Short, Nora S. Matthews
    Pages 90-99
  9. Jeffrey E. Fletcher, Henry Rosenberg
    Pages 121-140
  10. Michael Denborough
    Pages 141-146
  11. Mark G. Zukaitis, George P. Hoech Jr., John D. Robinson
    Pages 147-153
  12. J. Hilary Green, F. Richard Ellis, P. Jane Halsall, Iain T. Campbell
    Pages 155-160
  13. Back Matter
    Pages 161-166

About this book


Malignant hyperthermia is a genetic disease that causes an extremely high body temperature. The syndrome is triggered by depolarizing muscle relaxants and halogenated gaseous anesthetics, such as halothane. The purpose of the book is to present the latest experimental work and important conclusions to anesthesiologists, surgeons, certified registered nurse anesthesists, operating nurses, cardiovascular and temperature oriented physiologists, basic research scientists interested in heat production in muscle, animal scientists, primarily swine physiologists, and finally, muscle biology scientists. The results are based on sixteen years of experimental investigations with a malignant hyperthermia susceptible pig colony. Consequently, the data and conclusions are more concrete than the clinical data from human patients. The first five chapters present fresh material relating to the detailed biochemical mechanism of heat production during malignant hyperthermia. Subsequent chapters present recent data on malignant hyperthermia in horses and dogs; these additional animal models provide useful material for future studies of malignant hyperthermia pathophysiology. Later sections summarize the laboratory methods currently used for diagnosing malignant hyperthermia in human patients and present valuable data on malignant hyperthermia in the greater Kansas city area over a twenty year period.


Laboratory biology cardiovascular catecholamines diagnosis drugs dynamics hemodynamics hyperthermia muscle pathophysiology physiology plasma production research

Editors and affiliations

  • Charles H. Williams
    • 1
  1. 1.Regional Academic Health Center at El Paso Department of Surgery School of MedicineTexas Tech University Health Sciences CenterEl PasoUSA

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